AP3S1 blocking peptide

AP3S1 Antibody (N-term) Blocking Peptide

• Gene Names: AP3S1; CLAPS3; Sigma3A
• Synonyms: AP3S1; AP3S1 Antibody (N-term) Blocking Peptide; AP-3 complex subunit sigma-1; AP-3 complex subunit sigma-3A; Adaptor-related protein complex 3 subunit sigma-1; Clathrin-associated/assembly/adaptor protein; small 3; Sigma-3A-adaptin; Sigma3A-adaptin; Sigma-adaptin 3a; CLAPS3; AP3S1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 193

• Cellular Location: Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex
• Tissue Location: Present in all adult tissues examined.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for AP3S1 blocking peptide

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

NCBI and Uniprot Product Information

• NCBI GI #: 4502861
• NCBI GeneID: 1176
• NCBI Accession #: NP_001275.1
• NCBI GenBank Nucleotide #: NM_001284.3
• UniProt Accession #: Q92572; O00647; O00676; O00721; O00727; Q53XL4; Q6ICQ2
• Molecular Weight: 21,732 Da
• NCBI Official Full Name: AP-3 complex subunit sigma-1 isoform 1
• NCBI Official Synonym Full Names: adaptor related protein complex 3 sigma 1 subunit
• NCBI Official Symbol: AP3S1
• NCBI Official Synonym Symbols: CLAPS3; Sigma3A
• NCBI Protein Information: AP-3 complex subunit sigma-1
• UniProt Protein Name: AP-3 complex subunit sigma-1
• Protein Family: AP-3 complex
• UniProt Gene Name: AP3S1
• UniProt Synonym Gene Names: CLAPS3; Sigma3A-adaptin
• UniProt Entry Name: AP3S1_HUMAN

NCBI Description

This gene encodes a subunit of the AP3 adaptor complex. This complex functions in the formation of subcellular vesicles budded from the Golgi body. Several related pseudogenes of this gene have been found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Uniprot Description

AP3S1: Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Belongs to the adaptor complexes small subunit family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q22

Cellular Component: AP-type membrane coat adaptor complex; intracellular membrane-bound organelle; transport vesicle

Molecular Function: protein binding

Biological Process: anterograde axon cargo transport; anterograde synaptic vesicle transport; insulin receptor signaling pathway