Rabbit anti-Human PABPC5 Polyclonal Antibody | anti-PABPC5 antibody

PABPC5 Antibody (C-Term)

Cat. Num. AAA9216547

• Gene Names: PABPC5; PABP5
• Reactivity: Human
• Applications: Western Blot
• Synonyms: PABPC5; Polyclonal Antibody; PABPC5 Antibody (C-Term); Purified Rabbit Polyclonal Antibody (Pab); Polyadenylate-binding protein 5; PABP-5; Poly(A)-binding protein 5; PABP5; anti-PABPC5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This PABPC5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 287-321 amino acids from human PABPC5.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 382

• Applicable Applications for anti-PABPC5 antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:2000
• Antigen Source: Human
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(All lanes : Anti-PABPC5 Antibody (C-Term) at 1:2000 dilutionLane 1: MDA-MB-453 whole cell lysateLane 2: U-87 MG whole cell lysateLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 43 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-PABPC5 antibody

Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).

References

Blanco P.,et al.Genomics 74:1-11(2001). Ota T.,et al.Nat. Genet. 36:40-45(2004). Ross M.T.,et al.Nature 434:325-337(2005). Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. Bechtel S.,et al.BMC Genomics 8:399-399(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 18201888
• NCBI GeneID: 140886
• NCBI Accession #: NP_543022.1
• NCBI GenBank Nucleotide #: NM_080832.2
• UniProt Accession #: Q96DU9; Q5JQF4; Q6P529; Q9UFE5; A8K240
• Molecular Weight: 43331
• NCBI Official Full Name: polyadenylate-binding protein 5
• NCBI Official Synonym Full Names: poly(A) binding protein, cytoplasmic 5
• NCBI Official Symbol: PABPC5
• NCBI Official Synonym Symbols: PABP5
• NCBI Protein Information: polyadenylate-binding protein 5
• UniProt Protein Name: Polyadenylate-binding protein 5
• Protein Family: Polyadenylate-binding protein
• UniProt Gene Name: PABPC5
• UniProt Synonym Gene Names: PABP5; PABP-5; Poly(A)-binding protein 5
• UniProt Entry Name: PABP5_HUMAN

NCBI Description

This gene encodes a protein that binds to the polyA tail found at the 3' end of most eukaryotic mRNAs. It is thought to play a role in the regulation of mRNA metabolic processes in the cytoplasm. This gene is located in a gene-poor region within the X-specific 13d-sY43 subinterval of the chromosome Xq21.3/Yp11.2 homology block. It is located close to translocation breakpoints associated with premature ovarian failure, and is therefore a potential candidate gene for this disorder. [provided by RefSeq, May 2010]

Uniprot Description

PABPC5: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: Xq21.3

Cellular Component: mitochondrial matrix

Molecular Function: RNA binding; nucleotide binding