Western Blot (WB)
(CIC Antibody (N-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the CIC antibody detected the CIC protein (arrow).)
Rabbit anti-Human, mouse CIC Polyclonal Antibody | anti-CIC antibody
CIC Antibody (N-term)
Western Blot (WB)
(CIC Antibody (N-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the CIC antibody detected the CIC protein (arrow).)
Western Blot (WB)
(CIC Antibody (N-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the CIC antibody detected the CIC protein (arrow).)
Immunohistochemistry (IHC)
(CIC antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CIC antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(CIC antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CIC antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Yoshimoto, M., et al. Cancer Genet. Cytogenet. 195(1):1-11(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Uniprot Description
capicua: involved in cerebellar development and ErbB signaling. Significantly expressed in medulloblastomas.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: nucleus
Molecular Function: protein binding; DNA binding; chromatin binding
Biological Process: transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; alveolus development
Research Articles on CIC
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Product Notes
The CIC cic (Catalog #AAA9208757) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 174-203. The CIC Antibody (N-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CIC can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the CIC cic for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CIC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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