Western Blot (WB)
(Mouse Dab2 Antibody (C-term) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Mouse Dab2 antibody detected the Mouse Dab2 protein (arrow).)
Rabbit Dab2 Polyclonal Antibody | anti-Dab2 antibody
Mouse Dab2 Antibody (C-term)
Western Blot (WB)
(Mouse Dab2 Antibody (C-term) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Mouse Dab2 antibody detected the Mouse Dab2 protein (arrow).)
Western Blot (WB)
(Mouse Dab2 Antibody (C-term) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Mouse Dab2 antibody detected the Mouse Dab2 protein (arrow).)
Chaudhury, A., et al. Nat. Cell Biol. 12(3):286-293(2010)
Hasumi, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 106(44):18722-18727(2009)
Jain, N., et al. J. Immunol. 183(7):4192-4196(2009)
Jiang, Y., et al. Oncogene 28(33):2999-3007(2009)
NCBI and Uniprot Product Information
Uniprot Description
DAB2: an adaptor protein that interacts with Grb2, myosin VI, SMAD2/3, DIP1/2, Dvl-3, the integrin betasubunit, and c-Src. Negatively regulates canonical Wnt signaling by stabilizing the beta-catenin degradation complex. A component of the CSF-1 signal transduction pathway. Phosphorylated DAB2 inhibits adhesion and integrin signaling. Two alternatively spliced isoforms are described.
Protein type: Adaptor/scaffold; Tumor suppressor
Cellular Component: focal adhesion; clathrin-coated vesicle; intracellular membrane-bound organelle; clathrin coated vesicle membrane; coated pit; clathrin coat of coated pit; membrane; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; nucleolus; plasma membrane; cytoplasmic vesicle; nucleus
Molecular Function: integrin binding; protein C-terminus binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; clathrin binding; SMAD binding; phosphoinositide binding
Biological Process: pinocytosis; cellular morphogenesis during differentiation; positive regulation of cell adhesion; apoptosis; positive regulation of transcription, DNA-dependent; multicellular organismal development; positive regulation of endocytosis; excretion; activation of JNK activity; clathrin cage assembly; protein transport; positive regulation of aldosterone biosynthetic process; transport; positive regulation of RNA elongation from RNA polymerase II promoter; cell differentiation; negative regulation of protein binding; positive regulation of receptor recycling; negative regulation of epithelial cell proliferation; receptor-mediated endocytosis; Wnt receptor signaling pathway; leading edge cell differentiation; in utero embryonic development; positive regulation of transforming growth factor beta receptor signaling pathway; endocytosis; response to steroid hormone stimulus; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein amino acid phosphorylation; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; positive regulation of cell migration; negative regulation of apoptosis; endoderm development
Research Articles on Dab2
Similar Products
Product Notes
The Dab2 dab2 (Catalog #AAA9207439) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 624-650. The Mouse Dab2 Antibody (C-term) reacts with Mouse (Predicted Reactivity: Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's Dab2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the Dab2 dab2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Dab2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
