Western Blot (WB)
(CLCF1 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the CLCF1 antibody detected the CLCF1 protein (arrow).)
Rabbit CLCF1 Polyclonal Antibody | anti-CLCF1 antibody
CLCF1 Antibody (N-term)
Western Blot (WB)
(CLCF1 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the CLCF1 antibody detected the CLCF1 protein (arrow).)
Western Blot (WB)
(CLCF1 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the CLCF1 antibody detected the CLCF1 protein (arrow).)
family and encodes cardiotrophin-like cytokine factor 1 (CLCF1).
CLCF1 forms a heterodimer complex with cytokine receptor-like
factor 1 (CRLF1). This dimer competes with ciliary neurotrophic
factor (CNTF) for binding to the ciliary neurotrophic factor
receptor (CNTFR) complex, and activates the Jak-STAT signaling
cascade. CLCF1 can be actively secreted from cells by forming a
complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a
potent neurotrophic factor, B-cell stimulatory agent and
neuroendocrine modulator of pituitary corticotroph function.
Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2).
This syndrome is characterized by a profuse sweating after exposure
to cold as well as congenital physical abnormalities of the head
and spine. Alternative splicing results in multiple transcript
variants encoding distinct isoforms.
Dagoneau, N., et al. Am. J. Hum. Genet. 80(5):966-970(2007)
Rousseau, F., et al. Proc. Natl. Acad. Sci. U.S.A. 103(26):10068-10073(2006)
Perret, D., et al. J. Biol. Chem. 279(42):43961-43970(2004)
Burger, R., et al. Br. J. Haematol. 123(5):869-878(2003)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Uniprot Description
CLCF1: Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. Defects in CLCF1 are the cause of cold-induced sweating syndrome type 2 (CISS2). Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high- arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted; Cytokine; Apoptosis
Chromosomal Location of Human Ortholog: 11q13.3
Cellular Component: extracellular region
Molecular Function: protein binding; growth factor activity; protein heterodimerization activity; cytokine activity; ciliary neurotrophic factor receptor binding; receptor binding
Biological Process: positive regulation of immunoglobulin production; cell surface receptor linked signal transduction; B cell differentiation; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; positive regulation of B cell proliferation; negative regulation of neuron apoptosis; JAK-STAT cascade; positive regulation of isotype switching to IgE isotypes; positive regulation of astrocyte differentiation; positive regulation of tyrosine phosphorylation of Stat3 protein
Disease: Cold-induced Sweating Syndrome 2
Research Articles on CLCF1
Similar Products
Product Notes
The CLCF1 clcf1 (Catalog #AAA9206438) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 46-72. The CLCF1 Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's CLCF1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the CLCF1 clcf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CLCF1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
