Rabbit anti-Human SKOR2 Polyclonal Antibody | anti-SKOR2 antibody
SKOR2 Antibody (C-term)
Gene Names
SKOR2; CORL2; CH18515; FUSSEL18
Reactivity
Human
Applications
Western Blot, ELISA
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
SKOR2; Polyclonal Antibody; SKOR2 Antibody (C-term); SKI family transcriptional corepressor 2; Functional Smad-suppressing element on chromosome 18; Fussel-18; LBX1 corepressor 1-like protein; Ladybird homeobox corepressor 1-like protein; CORL2; FUSSEL18; anti-SKOR2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This SKOR2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 741-775 amino acids from the C-terminal region of human SKOR2.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Sequence Length
296
Applicable Applications for anti-SKOR2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB~~1:1000
Cellular Location
Nucleus.Cytoplasm
Tissue Location
Expressed in cerebellum, spinal cord and testis. Isoform 2 is present in cerebellum (at protein level)
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Western Blot (WB)
(Western blot analysis of lysates from human cerebellum, human testis, mouse cerebellum tissue lysate (from left to right), using SKOR2 Antibody (C-term). MBS9204741 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.)
Related Product Information for anti-SKOR2 antibody
Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system.
Product Categories/Family for anti-SKOR2 antibody
References
Arndt S.,et al.Lab. Invest. 85:1330-1341(2005).
Nusbaum C.,et al.Nature 437:551-555(2005).
Nusbaum C.,et al.Nature 437:551-555(2005).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
104235
NCBI Official Full Name
SKI family transcriptional corepressor 2 isoform 2
NCBI Official Synonym Full Names
SKI family transcriptional corepressor 2
NCBI Official Symbol
SKOR2
NCBI Official Synonym Symbols
CORL2; CH18515; FUSSEL18
NCBI Protein Information
SKI family transcriptional corepressor 2
UniProt Protein Name
SKI family transcriptional corepressor 2
Protein Family
UniProt Gene Name
SKOR2
UniProt Synonym Gene Names
CORL2; FUSSEL18; Fussel-18
UniProt Entry Name
SKOR2_HUMAN
Uniprot Description
FUSSEL18: Exhibits transcriptional repressor activity. Acts as a TGF-beta antagonist in the nervous system. Belongs to the SKI family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 18q21.1
Cellular Component: cytoplasm; nucleus
Molecular Function: SMAD binding; transcription corepressor activity
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway
Research Articles on SKOR2
1. Experiments performed using mice, but the observations maybe relevant to other organisms as well.
