Western Blot (WB)
(PSMD14 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the PSMD14 antibody detected the PSMD14 protein (arrow).)
Rabbit PSMD14 Polyclonal Antibody | anti-PSMD14 antibody
PSMD14 Antibody (C-term)
Western Blot (WB)
(PSMD14 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the PSMD14 antibody detected the PSMD14 protein (arrow).)
Western Blot (WB)
(PSMD14 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the PSMD14 antibody detected the PSMD14 protein (arrow).)
multiprotein complex that degrades proteins targeted for
destruction by the ubiquitin pathway (Spataro et al., 1997 [PubMed
9374539]).
Ma, Z., et al. Pediatr Int 51(5):732-735(2009)
Cooper, E.M., et al. EMBO J. 28(6):621-631(2009)
Koulich, E., et al. Mol. Biol. Cell 19(3):1072-1082(2008)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012]
Uniprot Description
PSMD14: a component of the 26S proteasome. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.
Protein type: EC 3.4.19.-; Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 2q24.2
Cellular Component: nucleoplasm; proteasome complex; cytosol; nucleus
Molecular Function: metallopeptidase activity; metal ion binding
Biological Process: ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
Research Articles on PSMD14
Similar Products
Product Notes
The PSMD14 psmd14 (Catalog #AAA9203590) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 258-287. The PSMD14 Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's PSMD14 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the PSMD14 psmd14 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PSMD14, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
