Western Blot (WB)
(DUSP6 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the DUSP6 antibody detected the DUSP6 protein (arrow).)
Rabbit DUSP6 Polyclonal Antibody | anti-DUSP6 antibody
DUSP6 Antibody (N-term)
Western Blot (WB)
(DUSP6 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the DUSP6 antibody detected the DUSP6 protein (arrow).)
Western Blot (WB)
(DUSP6 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the DUSP6 antibody detected the DUSP6 protein (arrow).)
Western Blot (WB)
(DUSP6 Antibody (N-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the DUSP6 antibody detected the DUSP6 protein (arrow).)
Western Blot (WB)
(DUSP6 Antibody (N-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the DUSP6 antibody detected the DUSP6 protein (arrow).)
Western Blot (WB)
(Western blot analysis of DUSP6 (arrow) using rabbit polyclonal DUSP6 Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the DUSP6 gene.)
Western Blot (WB)
(Western blot analysis of DUSP6 (arrow) using rabbit polyclonal DUSP6 Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the DUSP6 gene.)
specificity protein phosphatase subfamily. These phosphatases
inactivate their target kinases by dephosphorylating both the
phosphoserine/threonine and phosphotyrosine residues. They
negatively regulate members of the mitogen-activated protein (MAP)
kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated
with cellular proliferation and differentiation. Different members
of the family of dual specificity phosphatases show distinct
substrate specificities for various MAP kinases, different tissue
distribution and subcellular localization, and different modes of
inducibility of their expression by extracellular stimuli. This
gene product inactivates ERK2, is expressed in a variety of tissues
with the highest levels in heart and pancreas, and unlike most
other members of this family, is localized in the cytoplasm. Two
transcript variants encoding different isoforms have been found for
this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Nunes-Xavier, C.E., et al. J. Biol. Chem. 285(34):26417-26430(2010)
Zhang, Z., et al. Carcinogenesis 31(4):577-586(2010)
Wang, Z., et al. Mol. Vis. 16, 1696-1704 (2010) :
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
Uniprot Description
MKP-3: a non-receptor, dual-specificity phosphoprotein phosphatase. Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This protein inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two alternatively spliced isoforms have been described.
Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 12q22-q23
Cellular Component: nucleoplasm; cytoplasm; cytosol
Molecular Function: protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity
Biological Process: response to drug; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; regulation of fibroblast growth factor receptor signaling pathway; toll-like receptor 3 signaling pathway; response to organic cyclic substance; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; response to nitrosative stress; dorsal/ventral pattern formation; toll-like receptor signaling pathway; innate immune response; regulation of endodermal cell fate specification; toll-like receptor 9 signaling pathway; cell differentiation; toll-like receptor 4 signaling pathway; inactivation of MAPK activity
Disease: Hypogonadotropic Hypogonadism 19 With Or Without Anosmia
Research Articles on DUSP6
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Product Notes
The DUSP6 dusp6 (Catalog #AAA9203454) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 59-88. The DUSP6 Antibody (N-term) reacts with Human, mouse (Predicted Reactivity: Bovine) and may cross-react with other species as described in the data sheet. AAA Biotech's DUSP6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the DUSP6 dusp6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DUSP6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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