Western Blot (WB)
(PLA2G12A Antibody (Center) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the PLA2G12A antibody detected the PLA2G12A protein (arrow).)
Rabbit anti-Human PLA2G12A Polyclonal Antibody | anti-PLA2G12A antibody
PLA2G12A Antibody (Center)
Western Blot (WB)
(PLA2G12A Antibody (Center) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the PLA2G12A antibody detected the PLA2G12A protein (arrow).)
Western Blot (WB)
(PLA2G12A Antibody (Center) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the PLA2G12A antibody detected the PLA2G12A protein (arrow).)
Western Blot (WB)
(Western blot analysis of PLA2G12A (arrow) using rabbit polyclonal PLA2G12A Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PLA2G12A gene.)
Western Blot (WB)
(Western blot analysis of PLA2G12A (arrow) using rabbit polyclonal PLA2G12A Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PLA2G12A gene.)
arachidonic acid from phospholipids for production of eicosanoids
and exert a variety of physiologic and pathologic effects. Group
XII sPLA2s, such as PLA2G12A, have relatively low specific activity
and are structurally and functionally distinct from other sPLA2s
(Gelb et al., 2000 [PubMed 11031251]).
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)
Chen, W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7401-7406(2010)
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
NCBI and Uniprot Product Information
NCBI Description
Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]
Uniprot Description
PLA2G12A: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine. Belongs to the phospholipase A2 family.
Protein type: EC 3.1.1.4; Endoplasmic reticulum; Secreted, signal peptide; Lipid Metabolism - ether lipid; Lipid Metabolism - alpha-linolenic acid; Phospholipase; Lipid Metabolism - linoleic acid; Secreted; Lipid Metabolism - arachidonic acid; Lipid Metabolism - glycerophospholipid
Chromosomal Location of Human Ortholog: 4q25
Cellular Component: Golgi apparatus; endoplasmic reticulum; extracellular region
Molecular Function: calcium-dependent phospholipase A2 activity; calcium ion binding
Biological Process: phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; lipid catabolic process
Research Articles on PLA2G12A
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Product Notes
The PLA2G12A pla2g12a (Catalog #AAA9202505) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 55-83. The PLA2G12A Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PLA2G12A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the PLA2G12A pla2g12a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PLA2G12A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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