SDS-Page
(Recombinant Human TrkC/NTRK3 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 120 kDa.)
TrkC/NTRK3 active protein
Recombinant Human TrkC/NTRK3 Protein
After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.
SDS-Page
(Recombinant Human TrkC/NTRK3 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 120 kDa.)
SDS-Page
(Recombinant Human TrkC/NTRK3 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 120 kDa.)
Background: NT-3 growth factor receptor also known as neurotrophic tyrosine kinase receptor type 3 or TrkC tyrosine kinase or Trk-C receptor, is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in TrkC encoding gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Uniprot Description
TrkC: a receptor tyrosine kinase of the TRK family. Receptor for neurotrophin-3 (NT-3). Known substrates for the trk receptors are SHC, PI-3 kinase, and PLCG1. Four alternatively spliced isoforms are known.
Protein type: Kinase, protein; EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; Trk family
Chromosomal Location of Human Ortholog: 15q25
Cellular Component: integral to plasma membrane; cytoplasm; receptor complex
Molecular Function: neurotrophin binding; protein binding; ephrin receptor binding; p53 binding; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; ATP binding
Biological Process: circadian rhythm; mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; positive regulation of positive chemotaxis; activation of MAPK activity; positive regulation of axon extension involved in regeneration; protein amino acid autophosphorylation; activation of protein kinase B; neuron migration; positive regulation of peptidyl-serine phosphorylation; response to ethanol; negative regulation of protein amino acid phosphorylation; positive regulation of cell proliferation; negative regulation of astrocyte differentiation; modification by virus of host cell transcription; neuron fate specification; response to axon injury; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; response to corticosterone stimulus
Research Articles on TrkC/NTRK3
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Product Notes
The TrkC/NTRK3 ntrk3 (Catalog #AAA9141699) is an Active Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: CPANCVCSKT EINCRRPDDG NLFPLLEGQD SGNSNGNASI NITDISRNIT SIHIENWRSL HTLNAVDMEL YTGLQKLTIK NSGLRSIQPR AFAKNPHLRY INLSSNRLTT LSWQLFQTLS LRELQLEQNF FNCSCDIRWM QLWQEQGEAK LNSQNLYCIN ADGSQLPLFR MNISQCDLPE ISVSHVNLTV REGDNAVITC NGSGSPLPDV DWIVTGLQSI NTHQTNLNWT NVHAINLTLV NVTSEDNGFT LTCIAENVVG MSNASVALTV YYPPRVVSLE EPELRLEHCI EFVVRGNPPP TLHWLHNGQP LRESKIIHVE YYQEGEISEG CLLFNKPTHY NNGNYTLIAK NPLGTANQTI NGHFLKEPFP ESTDNFILFD EVSPTPPITV THKPEED. It is sometimes possible for the material contained within the vial of "TrkC/NTRK3, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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