Rabbit anti-Human NOX1 Polyclonal Antibody | anti-NOX1 antibody

NOX1 Polyclonal Antibody

Cat. Num. AAA9129867

• Gene Names: NOX1; MOX1; NOH1; NOH-1; GP91-2
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity purification
• Synonyms: NOX1; Polyclonal Antibody; NOX1 Polyclonal Antibody ; MOX1; NOH1; NOH-1; GP91-2; anti-NOX1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Sequence Length: 527

• Applicable Applications for anti-NOX1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500 - 1:2000
• Immunogen: Recombinant protein of human NOX1
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using NOX1 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 10s.)

Related Product Information for anti-NOX1 antibody

This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Product Categories/Family for anti-NOX1 antibody

Polyclonal

NCBI and Uniprot Product Information

• NCBI GI #: 425854820
• NCBI GeneID: 27035
• NCBI Accession #: NP_001258744.1
• NCBI GenBank Nucleotide #: NM_001271815.1
• UniProt Accession #: Q9Y5S8; O95691; Q2PP02; A8K836
• Molecular Weight: Calculated MW: 65kDa; Molecular Weight: 564
• NCBI Official Full Name: NADPH oxidase 1 isoform 3
• NCBI Official Synonym Full Names: NADPH oxidase 1
• NCBI Official Symbol: NOX1
• NCBI Official Synonym Symbols: MOX1; NOH1; NOH-1; GP91-2
• NCBI Protein Information: NADPH oxidase 1
• UniProt Protein Name: NADPH oxidase 1
• Protein Family: NADPH oxidase
• UniProt Gene Name: NOX1
• UniProt Synonym Gene Names: MOX1; NOH1; NOX-1; MOX-1
• UniProt Entry Name: NOX1_HUMAN

NCBI Description

This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

Uniprot Description

NOX1: NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Oxidoreductase; Membrane protein, multi-pass; Channel, misc.; Membrane protein, integral; EC 1.-.-.-

Chromosomal Location of Human Ortholog: Xq22

Cellular Component: cell junction; early endosome; integral to membrane; NADPH oxidase complex; plasma membrane

Molecular Function: metal ion binding; NADP binding; protein binding; Rac GTPase binding; superoxide-generating NADPH oxidase activity; voltage-gated proton channel activity

Biological Process: angiogenesis; cell migration; extracellular matrix organization and biogenesis; hydrogen peroxide metabolic process; inflammatory response; intracellular pH elevation; NADP metabolic process; positive regulation of cell proliferation; positive regulation of integrin biosynthetic process; positive regulation of JNK cascade; positive regulation of smooth muscle cell proliferation; proton transport; regulation of blood pressure; regulation of systemic arterial blood pressure by renin-angiotensin; respiratory burst; signal transduction; small GTPase mediated signal transduction; superoxide metabolic process; superoxide release