Human interleukin 17 receptor B ELISA Kit | IL17RB elisa kit

Human Interleukin-17 receptor B, IL17RB ELISA Kit

Cat. Num. AAA911729

• Gene Names: IL17RB; CRL4; EVI27; IL17BR; IL17RH1
• Reactivity: Human
• Synonyms: interleukin 17 receptor B; Human Interleukin-17 receptor B; IL17RB ELISA Kit; Human Interleukin-17 receptor B (IL17RB) ELISA kit; CRL4; EVI27; IL17BR; IL17RH1; MGC5245; IL-17B receptor; cytokine receptor CRL4; interleukin 17 receptor homolog 1; interleukin 17B receptor; IL17RB elisa kit

• Reactivity: Human
• Specificity: This assay has high sensitivity and excellent specificity for detection of human IL17RB. No significant cross-reactivity or interference between human IL17RB and analogues was observed.
• Sequence Length: 502

• Samples: Serum, plasma, tissue homogenates, cell lysates.
• Assay Type: Sandwich (Quantitative)
• Detection Range: 0.625 ng/ml-40 ng/ml.
• Sensitivity: 0.156 ng/ml.
• Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
• Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
• Preparation and Storage: Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Related Product Information for IL17RB elisa kit

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for IL17RB has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any IL17RB present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for IL17RB is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of IL17RB bound in the initial step. The color development is stopped and the intensity of the color is measured.

NCBI and Uniprot Product Information

• NCBI GI #: 27477074
• NCBI GeneID: 55540
• NCBI Accession #: NP_061195.2
• NCBI GenBank Nucleotide #: NM_018725.3
• UniProt Accession #: Q9NRM6; Q9BPZ0; Q9NRL4; Q9NRM5
• Molecular Weight: 55,885 Da
• NCBI Official Full Name: interleukin-17 receptor B
• NCBI Official Synonym Full Names: interleukin 17 receptor B
• NCBI Official Symbol: IL17RB
• NCBI Official Synonym Symbols: CRL4; EVI27; IL17BR; IL17RH1
• NCBI Protein Information: interleukin-17 receptor B; IL-17RB; IL-17Rh1; IL-17B receptor; IL-17 receptor B; cytokine receptor CRL4; IL-17 receptor homolog 1; cytokine receptor-like 4; interleukin 17B receptor; interleukin-17B receptor; interleukin 17 receptor homolog 1
• UniProt Protein Name: Interleukin-17 receptor B
• Protein Family: Interleukin-17 receptor
• UniProt Gene Name: IL17RB
• UniProt Synonym Gene Names: CRL4; EVI27; IL17BR; UNQ2501/PRO19612; IL-17 receptor B; IL-17RB; IL-17Rh1; IL17Rh1; IL-17B receptor
• UniProt Entry Name: I17RB_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]

Uniprot Description

IL17RB: Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: cell surface; membrane; integral to plasma membrane; cytoplasm; extracellular region

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-17 receptor activity

Biological Process: cytokine and chemokine mediated signaling pathway; defense response; regulation of cell growth