Pigeon Melanocyte Stimulating Hormone ELISA Kit | MSH elisa kit

Pigeon Melanocyte Stimulating Hormone ELISA Kit

• Gene Names: MC1R; CMM5; MSH-R; SHEP2
• Reactivity: Pigeon
• Synonyms: Melanocyte Stimulating Hormone; Pigeon Melanocyte Stimulating Hormone ELISA Kit; MSH elisa kit

• Reactivity: Pigeon
• Sequence Length: 317

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 119587080
• NCBI GeneID: 4157
• UniProt Accession #: Q01726; Q66K38; Q6UR93; Q8WWX6; Q8WWX7; Q96I33; Q96RU4; Q9UBF7; Q9UN58; Q9UN59; Q9UN60; Q9UN61
• Molecular Weight: 34,706 Da
• NCBI Official Full Name: melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
• NCBI Official Synonym Full Names: melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
• NCBI Official Symbol: MC1R
• NCBI Official Synonym Symbols: CMM5; MSH-R; SHEP2
• NCBI Protein Information: melanocyte-stimulating hormone receptor; MC1-R; melanotropin receptor
• UniProt Protein Name: Melanocyte-stimulating hormone receptor
• UniProt Gene Name: MC1R
• UniProt Synonym Gene Names: MSHR; MSH-R; MC1-R
• UniProt Entry Name: MSHR_HUMAN

NCBI Description

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]

Uniprot Description

MC1R: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Genetic variations in MC1R are a cause of susceptibility to cutaneous malignant melanoma type 5 (CMM5). Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16q24.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; hormone binding; melanocortin receptor activity; melanocyte stimulating hormone receptor activity; ubiquitin protein ligase binding; peptide receptor activity, G-protein coupled

Biological Process: melanin biosynthetic process; positive regulation of protein kinase B signaling cascade; G-protein signaling, coupled to cyclic nucleotide second messenger; UV protection; pigmentation; multicellular organismal development; positive regulation of cAMP biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; negative regulation of tumor necrosis factor production; sensory perception of pain

Disease: Albinism, Oculocutaneous, Type Ii; Melanoma, Cutaneous Malignant, Susceptibility To, 5; Increased Analgesia From Kappa-opioid Receptor Agonist, Female-specific; Skin/hair/eye Pigmentation, Variation In, 2