Rabbit anti-Human, Mouse YOD1 Polyclonal Antibody | anti-YOD1 antibody

YOD1 Polyclonal Antibody

Cat. Num. AAA8568008

• Gene Names: YOD1; DUBA8; OTUD2; PRO0907
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: YOD1; Polyclonal Antibody; YOD1 Polyclonal Antibody; anti-YOD1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
• Sequence Length: 304

• Applicable Applications for anti-YOD1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant protein of human YOD1 (NP_061036.3).
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Related Product Information for anti-YOD1 antibody

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants.

NCBI and Uniprot Product Information

• NCBI GI #: 444299626
• NCBI GeneID: 55432
• NCBI Accession #: NP_001263249.1
• NCBI GenBank Nucleotide #: NP_001263249.1
• UniProt Accession #: Q5VVQ6
• Molecular Weight: 33kDa; 38kDa
• NCBI Official Full Name: ubiquitin thioesterase OTU1 isoform 2
• NCBI Official Synonym Full Names: YOD1 deubiquitinase
• NCBI Official Symbol: YOD1
• NCBI Official Synonym Symbols: DUBA8; OTUD2; PRO0907
• NCBI Protein Information: ubiquitin thioesterase OTU1
• UniProt Protein Name: Ubiquitin thioesterase OTU1
• UniProt Gene Name: YOD1
• UniProt Synonym Gene Names: DUBA8; HIN7; OTUD2; HIN-7; HsHIN7
• UniProt Entry Name: OTU1_HUMAN

NCBI Description

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Uniprot Description

YOD1: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Able to cleave both polyubiquitin and di- ubiquitin. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Lipid Metabolism - unsaturated fatty acid biosynthesis; Ubiquitin-specific protease; C2H2-type zinc finger protein; EC 3.4.19.12; Secondary Metabolites Metabolism - limonene and pinene degradation

Chromosomal Location of Human Ortholog: 1q32.2

Molecular Function: protein binding; metal ion binding; ubiquitin-specific protease activity

Biological Process: ER-associated protein catabolic process; unfolded protein response