Western Blot (WB)
(Western Blot analysis of Profilin 2 in Human fetal brain tissue using Profilin 2 Rabbit pAb at dilution 1/450)
Rabbit Profilin 2 Polyclonal Antibody | anti-PFN2 antibody
Profilin 2 Rabbit pAb
IHC-P: 1:25-1:100
Western Blot (WB)
(Western Blot analysis of Profilin 2 in Human fetal brain tissue using Profilin 2 Rabbit pAb at dilution 1/450)
Western Blot (WB)
(Western Blot analysis of Profilin 2 in Human fetal brain tissue using Profilin 2 Rabbit pAb at dilution 1/450)
Immunohistochemistry (IHC)
(Immunohistochemistry of Profilin 2 in paraffin-embedded Human brain tissue using Profilin 2 Rabbit pAb at dilution 1/30. Predicted cell location: Cytoplasm)
Immunohistochemistry (IHC)
(Immunohistochemistry of Profilin 2 in paraffin-embedded Human brain tissue using Profilin 2 Rabbit pAb at dilution 1/30. Predicted cell location: Cytoplasm)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
profilin 2: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Belongs to the profilin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Actin-binding
Chromosomal Location of Human Ortholog: 3q25.1
Cellular Component: cytoskeleton; cytoplasm; terminal button
Molecular Function: actin monomer binding; protein binding; phosphatidylinositol-4,5-bisphosphate binding; adenyl-nucleotide exchange factor activity
Biological Process: positive regulation of actin filament polymerization; positive regulation of ATPase activity; negative regulation of actin filament polymerization; positive regulation of stress fiber formation; positive regulation of actin filament bundle formation; actin cytoskeleton organization and biogenesis; positive regulation of peptidyl-serine phosphorylation
Research Articles on PFN2
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Product Notes
The PFN2 pfn2 (Catalog #AAA4760634) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Profilin 2 Rabbit pAb reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Profilin 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). WB: 1:500-1:2000 IHC-P: 1:25-1:100. Researchers should empirically determine the suitability of the PFN2 pfn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Profilin 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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