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Western Blot (WB) (Western blot analysis of extracts from K562 cells and COS cells, using PLEKHG4 antibody.)

anti-Human, Mouse PLEKHG4 Antibody | anti-PLEKHG4 antibody

PLEKHG4 Antibody

Gene Names
PLEKHG4; SCA4; PRTPHN1; ARHGEF44
Reactivity
Human, Mouse
Applications
Western Blot, ELISA
Purity
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
PLEKHG4; PLEKHG4 Antibody; PKHG4; pleckstrin homology domain containing; family G (with RhoGef domain) member 4; pleckstrin homology domain-containing family G member 4; PRTPHN1; puratrophin-1; puratrophin1; purkinje cell atrophy-associated protein 1; SCA4; anti-PLEKHG4 antibody
Ordering
For Research Use Only!
Reactivity
Human, Mouse
Specificity
PLEKHG4 antibody detects endogenous levels of total PLEKHG4 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Sequence Length
1191
Applicable Applications for anti-PLEKHG4 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB: 1:500~1:1000
ELISA: 1:20000
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human PLEKHG4.
Preparation and Storage
Store at-20 degree C for 1 year.

Western Blot (WB)

(Western blot analysis of extracts from K562 cells and COS cells, using PLEKHG4 antibody.)

Western Blot (WB) (Western blot analysis of extracts from K562 cells and COS cells, using PLEKHG4 antibody.)
References
Ishikawa K., Am. J. Hum. Genet. 77:280-296(2005). Ota T., Nat. Genet. 36:40-45(2004). The MGC Project Team; Genome Res. 14:2121-2127(2004).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
20,247 Da
NCBI Official Full Name
puratrophin-1 isoform 1
NCBI Official Synonym Full Names
pleckstrin homology and RhoGEF domain containing G4
NCBI Official Symbol
PLEKHG4
NCBI Official Synonym Symbols
SCA4; PRTPHN1; ARHGEF44
NCBI Protein Information
puratrophin-1
UniProt Protein Name
Puratrophin-1
Protein Family
UniProt Gene Name
PLEKHG4
UniProt Synonym Gene Names
PRTPHN1; PH domain-containing family G member 4

NCBI Description

The protein encoded by this gene can function as a guanine nucleotide exchange factor (GEF) and may play a role in intracellular signaling and cytoskeleton dynamics at the Golgi apparatus. Polymorphisms in the region of this gene have been found to be associated with spinocerebellar ataxia in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Uniprot Description

Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi.CautionDefects in PLEKHG4 were initially thought (PubMed:16001362) to be the cause of spinocerebellar ataxia 16q22-linked. However, it was later shown (PubMed:17611710) that it is not the case. Spinocerebellar ataxia 16q22-linked, also known as spinocerebellar ataxia type 31 (SCA31), is caused by defects in BEAN gene.

Research Articles on PLEKHG4

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Product Notes

The PLEKHG4 plekhg4 (Catalog #AAA852488) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The PLEKHG4 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PLEKHG4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:500~1:1000 ELISA: 1:20000. Researchers should empirically determine the suitability of the PLEKHG4 plekhg4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PLEKHG4, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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