GRB14 Antibody | anti-GRB14 antibody

GRB14 Antibody

Cat. Num. AAA852479

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: GRB14; GRB14 Antibody; growth factor receptor-bound protein 14; anti-GRB14 antibody

• Reactivity: Human, Mouse, Rat
• Specificity: GRB14 antibody detects endogenous levels of total GRB14 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 453

• Applicable Applications for anti-GRB14 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; ELISA: 1:40000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human GRB14.
• Preparation and Storage: Store at-20 degree C for 1 year.

Western Blot (WB)

(Western blot analysis of extracts from COLO cells, HUVEC cells and MCF-7 cells, using GRB14 antibody.)

Product Categories/Family for anti-GRB14 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Daly R.J., J. Biol. Chem. 271:12502-12510(1996). The MGC Project Team; Genome Res. 14:2121-2127(2004). Depetris R.S., Mol. Cell 20:325-333(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 742068549
• NCBI GeneID: 2888
• NCBI Accession #: NP_001290351.1
• NCBI GenBank Nucleotide #: NM_001303422.1
• UniProt Accession #: Q14449; Q7Z6I1; B7Z7F9
• Molecular Weight: 51,946 Da
• NCBI Official Full Name: growth factor receptor-bound protein 14 isoform 2
• NCBI Official Synonym Full Names: growth factor receptor bound protein 14
• NCBI Official Symbol: GRB14
• NCBI Protein Information: growth factor receptor-bound protein 14
• UniProt Protein Name: Growth factor receptor-bound protein 14
• Protein Family: Growth factor receptor-bound protein
• UniProt Gene Name: GRB14

NCBI Description

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Uniprot Description

Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.