CLCN3 Antibody | anti-CLCN3 antibody

CLCN3 Antibody

Cat. Num. AAA8516988

• Gene Names: CLCN3; CLC3; ClC-3
• Synonyms: CLCN3; CLCN3 Antibody; anti-CLCN3 antibody

• Sequence Length: 791

Western Blot (WB)

(Western blot analysis CLCN3 using HepG2 whole cell lysates)

NCBI and Uniprot Product Information

• NCBI GI #: 343478299
• NCBI GeneID: 1182
• NCBI Accession #: NP_001230301.1
• NCBI GenBank Nucleotide #: NM_001243372.1
• UniProt Accession #: P51790; O14918; Q86Z21; B7Z932; B9EGJ9; D3DP34; E9PB97
• Molecular Weight: 88,781 Da
• NCBI Official Full Name: H(+)/Cl(-) exchange transporter 3 isoform a
• NCBI Official Synonym Full Names: chloride voltage-gated channel 3
• NCBI Official Symbol: CLCN3
• NCBI Official Synonym Symbols: CLC3; ClC-3
• NCBI Protein Information: H(+)/Cl(-) exchange transporter 3
• UniProt Protein Name: H(+)/Cl(-) exchange transporter 3
• Protein Family: H(+)/Cl(-) exchange transporter
• UniProt Gene Name: CLCN3
• UniProt Synonym Gene Names: ClC-3

NCBI Description

This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Uniprot Description

Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.