Testing Data
Zibotentan, Inhibitor
Zibotentan (ZD4054)
Synonyms
Zibotentan; Zibotentan (ZD4054); inhibitor
Solubility
DMSO >=14 mg/mL - Water <1 mg/mL - Ethanol <1 mg/mL
Formula
C19H16N6O4S
CAS Number
186497-07-4
Preparation and Storage
Stable for; 2 years at -20 degree C Powder
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
Testing Data
Testing Data
Related Product Information for Zibotentan, inhibitor
Zibotentan (ZD4054)is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM). It was first evaluated as a potential treatment for pulmonary arterial hypertension in the late 1990s. Subsequently, interest switched to the role of endothelins in cancer, particularly hormone-resistant prostate cancer (HRPC). In vitro, Zibotentan (ZD4054) has been shown to compete with 125I-ET-1 for binding to the cloned human ETA-receptor with an IC50 value of 21 nM. No binding to the ETB receptor was observed with concentrations of zibotentan in excess of 10 muM. This agent is capable of inhibiting or reducing the multitude of effects that are evoked by ET-1 activation of the ETA receptor and which promote tumor survival, growth and progression. Zibotentan (ZD4054)treatment produced significant inhibition of tumor growth in ovarian and breast xenografts.[1]
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Product Notes
The Zibotentan (Catalog #AAA8506448) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Zibotentan, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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