Testing Data
NVP-AEW541, inhibitor
NVP-AEW541
Purity
0.99
Synonyms
NVP-AEW541; inhibitor
Purity/Purification
0.99
Solubility
DMSO >=88mg/mL - Water <1mg/mL - Ethanol >=88mg/mL
Formula
C27H29N5O
CAS Number
475489-16-8
Preparation and Storage
Store at-20 degree C 2 years.
Testing Data
Testing Data
Related Product Information for NVP-AEW541, inhibitor
NVP-AEW541 is an IGF-IR inhibitor with an IC50 of median 3.6 muM. NVP-AEW541 is a pyrrolo[2, 3-d]pyrimidine derivative highly selective against IGF-IR, compared with the insulin receptor and other tyrosine kinases. In a panel of 10 neuroblastoma cell lines positive for IGF-IR expression, NVP-AEW541 inhibited in vitro proliferation in a submicromolar/micromolar (0.4-6.8) range of concentrations. NVP-AEW541 inhibits IGF-I-mediated receptor activation and downstream signaling. In addition to growth inhibition, NVP-AEW541 also induced apoptosis in vitro. Oral administration of NVP-AEW541 (50 mg/kg twice daily) inhibited tumor growth of neuroblastoma xenografts in nude mice. Therapeutic potential of NVP-AEW541 was also analyzed in Ewing's sarcoma, osteosarcoma, rhabdomyosarcoma, and pancreatic cancer. [1][2]
Product Categories/Family for NVP-AEW541, inhibitor
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Product Notes
The NVP-AEW541 (Catalog #AAA8506317) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NVP-AEW541, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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