PHT-427, inhibitor
PHT-427
Purity
>99%
Synonyms
PHT-427; inhibitor
Purity/Purification
>99%
Solubility
DMSO >=82mg/mL - Water >=5mg/mL - Ethanol >=82mg/mL
Formula
C20H31N3O2S2
CAS Number
1191951-57-1
Preparation and Storage
Store at-20 degree C 2 years.
Testing Data
(PHT-427 is a dual Akt and PDPK1 inhibitor that affects downstream targetsamong sensitive but not resistant cells and tumor xenografts. When given orally, PHT-427 inhibited the growth of human tumor xenografts in immunodeficient mice, with up to 80% inhibition in the most sensitive tumors, and showed greater activity than analogues with C4, C6, or C8 alkyl chains. Inhibition of PDPK1 was more closely correlated to antitumor activity than Akt inhibition. [1])
Related Product Information for PHT-427, inhibitor
PHT-427 is a dual Akt and PDPK1 inhibitor that affects downstream targetsamong sensitive but not resistant cells and tumor xenografts. When given orally, PHT-427 inhibited the growth of human tumor xenografts in immunodeficient mice, with up to 80% inhibition in the most sensitive tumors, and showed greater activity than analogues with C4, C6, or C8 alkyl chains. Inhibition of PDPK1 was more closely correlated to antitumor activity than Akt inhibition. [1]
Product Categories/Family for PHT-427, inhibitor
