Structure
HS-1371 Biochemical
HS-1371
Purity
>=98% by HPLC
Synonyms
HS-1371; 4- (4-methylphenoxy)-7- (1-piperidin-4-ylpyrazol-4-yl) quinoline; EX-A2073; HS1371; HS-1371 biochemical
Purity/Purification
>=98% by HPLC
Form/Format
Crystalline solid
Solubility
>10 mg/ml DMSO
Molecular Formula
C??H??N??O
CAS Number
2158197-70-5
PubChem CID
134817449
SMILES
CC1=CC=C (C=C1)OC2=C3C=CC (=CC3=NC=C2)C4=CN (N=C4)C5CCNCC5
InChi
InChI=1S/C24H24N4O/c1-17-2-5-21 (6-3-17)29-24-10-13-26-23-14-18 (4-7-22 (23)24)19-15-27-28 (16-19)20-8-11-25-12-9-20/h2-7,10,13-16,20,25H,8-9,11-12H2,1H3
InChi Key
VPVLPCIBKVWFDT-UHFFFAOYSA-N
Preparation and Storage
Store at -20 degree C
Shelf life: ~36 months
Shelf life: ~36 months
Structure
Structure
Related Product Information for HS-1371 biochemical
HS-1371 is a potent RIP3 kinase inhibitor (IC50 = 20.8 nM). It binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro.. It inhibits TNF-induced necroptosis but does not inhibit TNF-induced apoptosis, indicating that HS-1371 has a specific inhibitory effect on RIP3-mediated necroptosis via the suppression of RIP3 kinase activity.
Product Categories/Family for HS-1371 biochemical
References
https://pubchem.ncbi.nlm.nih.gov/compound/134817449#section=Top
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Product Notes
The HS-1371 (Catalog #AAA848706) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "HS-1371, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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