Rabbit anti-Human KAL1 Polyclonal Antibody | anti-KAL1 antibody

KAL1, NT (KAL1, ADMLX, KAL, KALIG1, Anosmin-1, Adhesion molecule-like X-linked, Kallmann syndrome protein) (Biotin)

Cat. Num. AAA6311985

• Gene Names: KAL1; HH1; HHA; KAL; KMS; ADMLX; WFDC19; KALIG-1
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KAL1; Polyclonal Antibody; NT (KAL1; ADMLX; KAL; KALIG1; Anosmin-1; Adhesion molecule-like X-linked; Kallmann syndrome protein) (Biotin); Kallmann syndrome protein; anti-KAL1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-KAL1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-194 amino acids from the N-terminal region of human KAL1.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(KAL1 Antibody (N-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the KAL1 antibody detected the KAL1 protein (arrow).)

Related Product Information for anti-KAL1 antibody

Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity.

Product Categories/Family for anti-KAL1 antibody

Antibodies; Disease Markers

References

Dode, C., et al. Ann. Endocrinol. (Paris) 71(3):149-157(2010). Tengara, S., et al. J. Dermatol. Sci. 58(1):64-71(2010). Jian, B., et al. Cell Cycle 8(22):3770-3776(2009). Tang, K.F., et al. Asian J. Androl. 11(6):711-715(2009). Hu, Y., et al. J. Biol. Chem. 284(43):29905-29920(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 119395746
• NCBI GeneID: 3730
• NCBI Accession #: NP_000207.2
• NCBI GenBank Nucleotide #: NM_000216.2
• UniProt Accession #: P23352; B2RPF8
• Molecular Weight: 76,112 Da
• NCBI Official Full Name: anosmin-1
• NCBI Official Synonym Full Names: Kallmann syndrome 1 sequence
• NCBI Official Symbol: KAL1
• NCBI Official Synonym Symbols: HH1; HHA; KAL; KMS; ADMLX; WFDC19; KALIG-1
• NCBI Protein Information: anosmin-1; kallmann syndrome protein; adhesion molecule-like X-linked; Kallmann syndrome interval gene 1; WAP four-disulfide core domain 19; Kallmann syndrome-1 sequence (anosmin-1)
• UniProt Protein Name: Anosmin-1
• UniProt Gene Name: KAL1
• UniProt Synonym Gene Names: ADMLX; KAL; KALIG1
• UniProt Entry Name: KALM_HUMAN

NCBI Description

Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity. [provided by RefSeq, Jul 2008]

Uniprot Description

KAL1: Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex. Chemoattractant for fetal olfactory epithelial cells. Defects in KAL1 are the cause of Kallmann syndrome type 1 (KAL1); also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin- releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.

Protein type: Motility/polarity/chemotaxis; Extracellular matrix

Chromosomal Location of Human Ortholog: Xp22.32

Cellular Component: proteinaceous extracellular matrix; extracellular space; plasma membrane

Molecular Function: heparin binding; serine-type endopeptidase inhibitor activity; protein binding; extracellular matrix structural constituent

Biological Process: axon guidance; chemotaxis; cell adhesion; cell motility

Disease: Hypogonadotropic Hypogonadism 1 With Or Without Anosmia