KLRK1 recombinant protein

KLRK1, human recombinant

Cat. Num. AAA844807

• Applications: SDS-Page
• Purity: >=90%
• Synonyms: KLRK1; human recombinant; NKG2-D type II integral membrane protein; CD314; D12S2489E; KLR; NKG2-D; NKG2D; KLRK1 recombinant protein

• Host: E Coli
• Purity/Purification: >=90%
• Form/Format: 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.; Appearance: Liquid
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMIWSAVF LNSLFNQEVQ IPLTESYCGP CPKNWICYKN NCYQFFDESK NWYESQASCM SQNASLLKVY SKEDQDLLKL VKSYHWMGLV HIPTNGSWQW EDGSILSPNL LTIIEMQKGD CALYASSFKG YIENCSTPNT YICMQRTV
• Sequence Length: 216

• Applicable Applications for KLRK1 recombinant protein: SDS-PAGE
• Handling: Centrifuge the vial prior to opening.
• Preparation and Storage: At -80 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for KLRK1 recombinant protein

Background: KLRK1 is an activating receptor that has recently generated considerable interest. The most intriguing of these are a pair of closely related proteins called MICA and MICB. These are cell-surface molecules distantly related to MHC class I proteins, and the genes possess elements of heat shock promoters. MICA and MICB, therefore, are expressed during cell stress and are up-regulated in tumor cells and during viral infections. This receptor-ligand combination may play a critical role in the immune response to a variety of pathologies. Recombinant human KLRK1 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Product Categories/Family for KLRK1 recombinant protein

Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Proteins and Enzymes (A-Z)

NCBI and Uniprot Product Information

• NCBI GI #: 315221164
• NCBI GeneID: 100528032
• NCBI Accession #: NP_001186734.1
• NCBI GenBank Nucleotide #: NM_001199805.1
• UniProt Accession #: P26718; Q9NR41; A8K7K5; A8K7P4
• Molecular Weight: 19.2 kDa (168 aa, 73-216 aa + His Tag), confirmed by MALDI-TOF.
• NCBI Official Full Name: NKG2-D type II integral membrane protein
• NCBI Official Synonym Full Names: KLRC4-KLRK1 readthrough
• NCBI Official Symbol: KLRC4-KLRK1
• NCBI Protein Information: NKG2-D type II integral membrane protein
• UniProt Protein Name: NKG2-D type II integral membrane protein
• Protein Family: NKG2-D type II integral membrane protein
• UniProt Gene Name: KLRK1
• UniProt Synonym Gene Names: D12S2489E; NKG2D
• UniProt Entry Name: NKG2D_HUMAN

NCBI Description

This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010]

Uniprot Description

KLRK1: Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.2-p12.3

Cellular Component: cell surface; integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: protein binding; receptor activity; carbohydrate binding

Biological Process: regulation of immune response; T cell costimulation; natural killer cell activation; innate immune response; signal transduction; cell differentiation; positive regulation of natural killer cell mediated cytotoxicity