NCBI and Uniprot Product Information
Uniprot Description
RAB3A: Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal. Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A. Interacts with the exocyst complex through SEC15. Binds SYTL4, RIMS1 and RIMS2. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3. Specifically expressed in brain. Belongs to the small GTPase superfamily. Rab family.
Protein type: G protein, monomeric, Rab; G protein; G protein, monomeric
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: synaptic vesicle; protein complex; secretory granule membrane; axon; plasma membrane; acrosome; terminal button; cytosol; endosome; vesicle
Molecular Function: GTPase activity; protein C-terminus binding; protein binding; ATPase activator activity; GTPase binding; GDP binding; GTP binding; myosin V binding; ATPase binding
Biological Process: mitochondrion organization and biogenesis; synaptic vesicle maturation; metabolic process; regulation of synaptic vesicle fusion to presynaptic membrane; neurotransmitter secretion; constitutive secretory pathway; protein secretion; regulation of short-term neuronal synaptic plasticity; post-embryonic development; intracellular protein transport; respiratory system process; synaptic transmission; synaptic vesicle exocytosis; glutamate secretion; axonogenesis; positive regulation of ATPase activity; sensory perception of touch; maintenance of presynaptic active zone structure; neuromuscular synaptic transmission; Rab protein signal transduction; response to electrical stimulus; vesicle docking during exocytosis; lung development; positive regulation of exocytosis
Research Articles on RAB3A
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Product Notes
The RAB3A rab3a (Catalog #AAA834219) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's RAB3A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Optimal conditions to be determined by the end user. Researchers should empirically determine the suitability of the RAB3A rab3a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RAB3A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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