Rabbit GPBP Polyclonal Antibody | anti-GPBP antibody

Anti-GPBP Antibody

Cat. Num. AAA8306340

• Gene Names: COL4A3BP; CERT; GPBP; CERTL; STARD11
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Purified by Immunogen Affinity Chromatography
• Synonyms: GPBP; Polyclonal Antibody; Anti-GPBP Antibody; CERT; STARD11; Collagen type IV alpha-3-binding protein; Ceramide transfer protein; hCERT; Goodpasture antigen-binding protein; START domain-containing protein 11; StARD11; StAR-related lipid transfer protein 11; anti-GPBP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of GPBP protein.
• Purity/Purification: Purified by Immunogen Affinity Chromatography
• Form/Format: Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.

• Applicable Applications for anti-GPBP antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant fusion protein of human GPBP. The exact sequence is proprietary.
• Preparation and Storage: Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of GPBP expression in HeLa (A), mouse brain (B), mouse heart (C) whole cell lysates.)

Related Product Information for anti-GPBP antibody

Rabbit polyclonal antibody to GPBP

NCBI and Uniprot Product Information

• NCBI GI #: 5031717
• NCBI GeneID: 10087
• NCBI Accession #: NP_005704.1
• NCBI GenBank Nucleotide #: NM_005713.2
• UniProt Accession #: Q9Y5P4; Q9EQG9
• Molecular Weight: 70,835 Da
• NCBI Official Full Name: collagen type IV alpha-3-binding protein isoform 1
• NCBI Official Synonym Full Names: collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
• NCBI Official Symbol: COL4A3BP
• NCBI Official Synonym Symbols: CERT; GPBP; CERTL; STARD11
• NCBI Protein Information: collagen type IV alpha-3-binding protein; hCERT; ceramide transporter; ceramide transfer protein; lipid-transfer protein CERTL; StAR-related lipid transfer (START) domain containing 11
• UniProt Protein Name: Collagen type IV alpha-3-binding protein
• UniProt Gene Name: COL4A3BP
• UniProt Synonym Gene Names: CERT; STARD11; hCERT; GPBP; StARD11
• UniProt Entry Name: C43BP_HUMAN

NCBI Description

This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

COL4A3BP: a protein with a lipid-binding domain that mediates intracellular trafficking of ceramide in a non-vesicular manner. Implicated in human autoimmune diseases via its association with the Goodpasture antigen. Phosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. GPBP has been reported to have Ser/Thr protein kinase activity towards the Goodpasture (GP) antigen, but lacks a conventional serine/threonine kinase domain. Two human isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.9; Lipid-binding; Kinase, protein; Protein kinase, atypical; ATYPICAL group; COL4A3BP family

Chromosomal Location of Human Ortholog: 5q13.3

Cellular Component: nucleoplasm; Golgi apparatus; endoplasmic reticulum membrane; mitochondrion; perinuclear region of cytoplasm; cytosol

Molecular Function: protein binding; protein kinase activity

Biological Process: heart morphogenesis; endoplasmic reticulum organization and biogenesis; sphingolipid metabolic process; sphingolipid biosynthetic process; in utero embryonic development; cell morphogenesis; lipid homeostasis; signal transduction; protein amino acid phosphorylation; cell proliferation; muscle contraction; immune response; ceramide metabolic process

Disease: Mental Retardation, Autosomal Dominant 34