Rabbit anti-Human, Mouse RGS14 Polyclonal Antibody | anti-RGS14 antibody

Anti-RGS14 Antibody

Cat. Num. AAA8292785

• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by immunogen affinity chromatography
• Synonyms: RGS14; Polyclonal Antibody; Anti-RGS14 Antibody; Regulator of G-protein signaling 14; anti-RGS14 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of RGS14 protein.
• Purity/Purification: Purified by immunogen affinity chromatography
• Form/Format: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
• Sequence Length: 347

• Applicable Applications for anti-RGS14 antibody: Western Blot (WB)
• Application Notes: WB: 1/500 - 1/2000
• Immunogen: Recombinant full length protein of human RGS14
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of RGS14 expression in SHSY5Y (A), mouse kidney (B) whole cell lysates.)

Related Product Information for anti-RGS14 antibody

Rabbit polyclonal antibody to RGS14

NCBI and Uniprot Product Information

• NCBI GI #: 21361304
• NCBI GeneID: 10636
• NCBI Accession #: NP_006471.2
• NCBI GenBank Nucleotide #: NM_006480.4
• UniProt Accession #: O43566; O43565; Q506M1; Q6ZWA4; Q8TD62
• Molecular Weight: 36,922 Da
• NCBI Official Full Name: regulator of G-protein signaling 14
• NCBI Official Synonym Full Names: regulator of G protein signaling 14
• NCBI Official Symbol: RGS14
• NCBI Protein Information: regulator of G-protein signaling 14
• UniProt Protein Name: Regulator of G-protein signaling 14
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: RGS14
• UniProt Synonym Gene Names: RGS14

NCBI Description

This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory.