PROCR recombinant protein

Recombinant Human PROCR Protein

Cat. Num. AAA8249653

• Gene Names: PROCR; CCCA; EPCR; CCD41
• Reactivity: Human
• Applications: ELISA, Western Blot, SDS-Page
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Synonyms: PROCR; Recombinant Human PROCR Protein; EPCR; Endothelial protein C receptor; Activated protein C receptor; APC receptor; Endothelial cell protein C receptor; CD201; PROCR recombinant protein

• Host: Human cells
• Reactivity: Human
• Purity/Purification: Greater than 95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 muM filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
• Sequence: SQDASDGLQR LHMLQISYFR DPYHVWYQGN ASLGGHLTHV LEGPDTNTTI IQLQPLQEPE SWARTQSGLQ SYLLQFHGLV RLVHQERTLA FPLTIRCFLG CELPPEGSRA HVFFEVAVNG SSFVSFRPER ALWQADTQVT SGVVTFTLQQ LNAYNRTRYE LREFLEDTCV QYVQKHISAE NTKGSQTSRS YTSVDHHHHH H
• Sequence Length: 238

• Applicable Applications for PROCR recombinant protein: ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
• Endotoxin: Less than 0.1 ng/mug (1 IEU/mug) as determined by LAL test.
• Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Preparation and Storage: Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.

Related Product Information for PROCR recombinant protein

Recombinant Human PROCR Protein is produced by our mammalian expression system and the target gene encoding Ser18-Ser210 is expressed with a 6His tag at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 34335272
• NCBI GeneID: 10544
• NCBI Accession #: NP_006395.2
• NCBI GenBank Nucleotide #: NM_006404.4
• UniProt Accession #: Q9UNN8; Q14218; Q6IB56; Q96CB3; Q9ULX1; B2RC04
• Molecular Weight: 26,671 Da
• NCBI Official Full Name: endothelial protein C receptor
• NCBI Official Synonym Full Names: protein C receptor
• NCBI Official Symbol: PROCR
• NCBI Official Synonym Symbols: CCCA; EPCR; CCD41
• NCBI Protein Information: endothelial protein C receptor
• UniProt Protein Name: Endothelial protein C receptor
• Protein Family: Endothelial protein C receptor
• UniProt Gene Name: PROCR
• UniProt Synonym Gene Names: EPCR; APC receptor
• UniProt Entry Name: EPCR_HUMAN

NCBI Description

The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]

Uniprot Description

EPCR: a single-pass type I membrane protein. Binds activated protein C (APC), a serine protease that regulates thrombin (IIa) production. Plays a pivotal role in preventing blood coagulation through binding of activated protein C. Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. The binding of APC to EPCR and PAR-1 increases invasion and chemotaxis.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 20q11.2

Cellular Component: cell surface; extracellular region; focal adhesion; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: blood coagulation; leukocyte migration; negative regulation of coagulation