PGII/PepsinogenII/PGC/Pepsinogen C Recombinant Protein | PGII recombinant protein

Recombinant Human PGII/PepsinogenII/PGC/Pepsinogen C protein, C-His Tag

Cat. Num. AAA157991

• Gene Names: PGC; PEPC; PGII
• Purity: >90% as determined by SDS-PAGE
• Synonyms: PGII/PepsinogenII/PGC/Pepsinogen C; Recombinant Human PGII/PepsinogenII/PGC/Pepsinogen C protein; C-His Tag; PGII recombinant protein

• Host: Mammalian cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from 50 mM Tris-HCl pH 7.4, 150 mM NaCl, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Human
• Endotoxin level: <1.0EU per ug of the protein as determined by the LAL method
• Reconstitution: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details
• Construction: A DNA sequence encoding the human PGC (Met1~Ala388) was fused with the C-terminal His Tag
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; Shipping: In general, proteins are provided as lyophilized powder/frozen liquid.

SDS-Page

Product Categories/Family for PGII recombinant protein

Other proteins; IVD material

NCBI and Uniprot Product Information

• NCBI GI #: 129796
• NCBI GeneID: 5225
• UniProt Accession #: P20142; Q5T3D7; Q5T3D8; B4DVZ3
• Molecular Weight: 388
• NCBI Official Full Name: Gastricsin
• NCBI Official Synonym Full Names: progastricsin (pepsinogen C)
• NCBI Official Symbol: PGC
• NCBI Official Synonym Symbols: PEPC; PGII
• NCBI Protein Information: gastricsin; pepsin C; pepsinogen C; preprogastricsin; pepsinogen group II
• UniProt Protein Name: Gastricsin
• UniProt Gene Name: PGC
• UniProt Entry Name: PEPC_HUMAN

NCBI Description

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

Uniprot Description

PGC: Hydrolyzes a variety of proteins. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Protease; Secreted; EC 3.4.23.3

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: extracellular space

Molecular Function: aspartic-type endopeptidase activity

Biological Process: digestion; proteolysis