FABP5 sirna

FABP5 siRNA (Mouse)

Cat. Num. AAA8232783

• Gene Names: Fabp5; Klbp; mal1; Fabpe; E-FABP; PA-FABP
• Reactivity: Mouse
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: FABP5; FABP5 siRNA (Mouse); FABPE; KLBP; MAL1; Fatty acid-binding protein. epidermal; Epidermal-type fatty acid-binding protein; E-FABP; Fatty acid-binding protein 5; Keratinocyte lipid-binding protein; Psoriasis-associated fatty acid-binding protein homolog; PA-FABP; FABP5 sirna

• Host: Synthetic
• Reactivity: Mouse
• Specificity: FABP5 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 135

• Applicable Applications for FABP5 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse FABP5 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for FABP5 sirna

siRNA to inhibit FABP5 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 6754450
• NCBI GeneID: 16592
• NCBI Accession #: NP_034764.1
• NCBI GenBank Nucleotide #: NM_010634.3
• UniProt Accession #: Q05816
• Molecular Weight: 15,137 Da
• NCBI Official Full Name: fatty acid-binding protein, epidermal isoform 1
• NCBI Official Synonym Full Names: fatty acid binding protein 5, epidermal
• NCBI Official Symbol: Fabp5
• NCBI Official Synonym Symbols: Klbp; mal1; Fabpe; E-FABP; PA-FABP
• NCBI Protein Information: fatty acid-binding protein, epidermal; uncharacterized protein LOC16592
• UniProt Protein Name: Fatty acid-binding protein, epidermal
• Protein Family: Fatty acid-binding protein
• UniProt Gene Name: Fabp5
• UniProt Synonym Gene Names: Fabpe; Klbp; Mal1; E-FABP; PA-FABP
• UniProt Entry Name: FABP5_MOUSE

NCBI Description

The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. In humans this gene has been associated with psoriasis and type 2 diabetes. In mouse deficiency of this gene in combination with a deficiency in Fabp4 confers protection against atherosclerosis, diet-induced obesity, insulin resistance and experimental autoimmune encephalomyelitis (the mouse model for multiple sclerosis). Alternative splicing results in multiple transcript variants that encode different protein isoforms. The mouse genome contains many pseudogenes similar to this locus. [provided by RefSeq, Jan 2013]

Uniprot Description

FABP5: High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Protein type: Lipid-binding

Cellular Component: cytoplasm

Molecular Function: transporter activity; fatty acid binding; lipid binding

Biological Process: transport; phosphatidylcholine biosynthetic process; glucose metabolic process; glucose transport; lipid metabolic process