STAB2 sirna

STAB2 siRNA (Human)

Cat. Num. AAA8209502

• Gene Names: STAB2; FEX2; HARE; FEEL2; FELL2; FELE-2
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: STAB2; STAB2 siRNA (Human); FEEL2; FELL; FEX2; HARE; Stabilin-2; FAS1 EGF-like and X-link domain-containing adhesion molecule 2; Fasciclin. EGF-like. laminin-type EGF-like and link domain-containing scavenger receptor 2; FEEL-2; Hyaluronan receptor for endocytosis; STAB2 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: STAB2 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 2551

• Applicable Applications for STAB2 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human STAB2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for STAB2 sirna

siRNA to inhibit STAB2 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 61743980
• NCBI GeneID: 55576
• NCBI Accession #: NP_060034.9
• NCBI GenBank Nucleotide #: NM_017564.9
• UniProt Accession #: Q8WWQ8; Q6ZMK2; Q7Z5N9; Q86UR4; Q8IUG9; Q8TES1; Q9H7H7; Q9NRY3
• Molecular Weight: 276,988 Da
• NCBI Official Full Name: stabilin-2
• NCBI Official Synonym Full Names: stabilin 2
• NCBI Official Symbol: STAB2
• NCBI Official Synonym Symbols: FEX2; HARE; FEEL2; FELL2; FELE-2
• NCBI Protein Information: stabilin-2
• UniProt Protein Name: Stabilin-2
• Protein Family: Stabilin
• UniProt Gene Name: STAB2
• UniProt Synonym Gene Names: FEEL-2
• UniProt Entry Name: STAB2_HUMAN

NCBI Description

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. [provided by RefSeq, Jul 2008]

Uniprot Description

STAB2: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q23.3

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane

Molecular Function: low-density lipoprotein receptor activity; protein binding; hyaluronic acid binding; low-density lipoprotein binding; protein disulfide oxidoreductase activity; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; glycosaminoglycan metabolic process; regulation of gene expression; carbohydrate metabolic process; defense response to bacterium; regulation of blood coagulation; pathogenesis; endocytosis; angiogenesis; cell adhesion; hyaluronan metabolic process; hyaluronan catabolic process