CLEC4A3 recombinant protein

CLEC4A3 Protein, Rat, Recombinant (His Tag)

Cat. Num. AAA8123458

• Gene Names: Clec4a3; Dcir3
• Purity: >95% as determined by SDS-PAGE
• Synonyms: CLEC4A3; CLEC4A3 Protein; Rat; Recombinant (His Tag); Rat CLEC4A3 Protein (His Tag); C-type lectin domain family 4; member a3; CLEC4A3 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Leu68-Leu237

• Species: Rat
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: His
• Tag: N-His
• Protein Construction: A DNA sequence encoding the rat CLEC4A3 (NP_001005891.1)(Leu68-Leu237) was expressed with a polyhistidine tag at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for CLEC4A3 recombinant protein

Background: CLEC4A3 contains 1 C-type lectin domain and belongs to the C-type lectin-like domain-containing (CLEC) family. Lectins are proteins that are able to recognize and bind with specific carbohydrate molecules. C-type lectins are an important group of proteins found in the immune system of animals. These lectins are named C-type because of their calcium dependent carbohydrate recognition domain (CRD). In the immune system, C-type lectins act as recognition molecules by binding to foreign microorganisms. They also promote the movement and selective adhesion of white blood cells. The C-type lectin has a three-dimensional fold, the CRD, in which calcium ions contribute to the lectin's ability to recognize and bind carbohydrates. In the immune system, carbohydrate recognition contributes to the ability of immune cells to move from one area of the body to another. It also allows immune cells to identify and discriminate between proteins that belong to the host and those that belong to foreign organisms. There are a number of different C-type lectin subfamilies, including collectins, selectins, proteoglycans, and lymphocyte lectins.

References

Gibbs RA, et al. (2004) Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature. 428:493-521. Carninci P, et al. (1999) High-efficiency full-length cDNA cloning. Methods Enzymol. 303:19-44. Shibata K, et al. (2000) RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Genome Res. 10:1757-71.

NCBI and Uniprot Product Information

• NCBI GI #: 54312112
• NCBI GeneID: 362431
• NCBI Accession #: NP_001005891.1
• NCBI GenBank Nucleotide #: NM_001005891.1
• UniProt Accession #: Q5YIS0
• Molecular Weight: 27,656 Da
• NCBI Official Full Name: C-type lectin domain family 4, member A3
• NCBI Official Synonym Full Names: C-type lectin domain family 4, member A3
• NCBI Official Symbol: Clec4a3
• NCBI Official Synonym Symbols: Dcir3
• NCBI Protein Information: C-type lectin domain family 4, member A3
• UniProt Protein Name: Dendritic cell inhibitory receptor 3
• UniProt Gene Name: Clec4a3