LAG3 recombinant protein

LAG3 Protein, Mouse, Recombinant (hFc Tag)

Cat. Num. AAA8123240

• Gene Names: Lag3; Ly66; CD223; LAG-3
• Purity: >95% as determined by SDS-PAGE
• Synonyms: LAG3; LAG3 Protein; Mouse; Recombinant (hFc Tag); Mouse LAG3/CD223/Lymphocyte activation gene 3 Protein (Fc Tag); CD223 Protein; LAG-3 Protein; Ly66 Protein; lymphocyte-activation gene 3; LAG3 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Arg432

• Species: Mouse
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Gly 24
• Tag: C-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the mouse Lag3 (NP_032505.1)(Met1-Arg432) was expressed with the Fc region of human IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for LAG3 recombinant protein

Background: LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfamily. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 contains 4 extracellular Ig-like domains and has a negative regulatory function in T cells. It also acts as a new marker of T cell-induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo. Diseases associated with LAG3 include Smoldering Myeloma and Kyphoscoliotic Heart Disease.

Product Categories/Family for LAG3 recombinant protein

Cancer Drug Targets

References

Sigrid Hannier. et al., 1998, The Journal of Immunology. 161(8): 4058-65. Triebel F. et al., 1990, J Exp Med. 171 (5): 1393-405. Baixeras E. et al., 1992, J Exp Med. 176 (2): 327-37. Huard B. et al., 1997, Proc Natl Acad Sci. 94 (11): 5744-9. Kisielow M. et al., 2005, Eur J Immunol. 35 (7): 2081-8.

NCBI and Uniprot Product Information

• NCBI GI #: 6678654
• NCBI GeneID: 16768
• NCBI Accession #: NP_032505.1
• NCBI GenBank Nucleotide #: NM_008479.2
• UniProt Accession #: Q61790; Q0VBL2
• Molecular Weight: 56,978 Da
• NCBI Official Full Name: lymphocyte activation gene 3 protein
• NCBI Official Synonym Full Names: lymphocyte-activation gene 3
• NCBI Official Symbol: Lag3
• NCBI Official Synonym Symbols: Ly66; CD223; LAG-3
• NCBI Protein Information: lymphocyte activation gene 3 protein
• UniProt Protein Name: Lymphocyte activation gene 3 protein
• Protein Family: Lymphocyte activation gene 3 protein
• UniProt Gene Name: Lag3
• UniProt Synonym Gene Names: LAG-3
• UniProt Entry Name: LAG3_MOUSE

Uniprot Description

LAG3: Involved in lymphocyte activation. Binds to HLA class-II antigens.

Protein type: Membrane protein, integral

Cellular Component: membrane; integral to membrane; external side of plasma membrane

Molecular Function: transmembrane receptor activity; MHC class II protein binding

Biological Process: cell surface receptor linked signal transduction; negative regulation of interleukin-2 biosynthetic process; positive regulation of natural killer cell mediated cytotoxicity; negative regulation of T cell activation