H Cadherin Recombinant Protein | CDH13 recombinant protein

H Cadherin Protein, Mouse, Recombinant (hFc Tag)

Cat. Num. AAA8123185

• Gene Names: Cdh13; Cdht; Tcad; T-cadherin; 4932416G01Rik
• Purity: >80% as determined by SDS-PAGE
• Synonyms: H Cadherin; H Cadherin Protein; Mouse; Recombinant (hFc Tag); Mouse CDH13/Cadherin-13/H Cadherin Protein (Fc Tag); 4932416G01Rik Protein; Cdht Protein; T-cadherin Protein; Tcad Protein; cadherin 13; CDH13 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >80% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Ala692

• Species: Mouse
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Asp 23
• Tag: C-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the mouse Cdh13 (NP_062681.2)(Met1-Ala692) was expressed with the Fc region of human IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for CDH13 recombinant protein

Background: CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer.

Product Categories/Family for CDH13 recombinant protein

Canonical Wnt Pathway

References

Hart AB. et al., 2012, PLoS One. 7 (8): e42646. Xu J. et al., 2012, BMC Cancer. 12: 243. Jo J. et al., 2012, Obesity (Silver Spring). 20 (8): 1683-7.

NCBI and Uniprot Product Information

• NCBI GI #: 110625609
• NCBI GeneID: 12554
• NCBI Accession #: NP_062681.2
• NCBI GenBank Nucleotide #: NM_019707.4
• UniProt Accession #: Q9WTR5; Q8BG11
• Molecular Weight: 78,186 Da
• NCBI Official Full Name: cadherin-13
• NCBI Official Synonym Full Names: cadherin 13
• NCBI Official Symbol: Cdh13
• NCBI Official Synonym Symbols: Cdht; Tcad; T-cadherin; 4932416G01Rik
• NCBI Protein Information: cadherin-13
• UniProt Protein Name: Cadherin-13
• Protein Family: Cadherin
• UniProt Gene Name: Cdh13
• UniProt Synonym Gene Names: H-cadherin; T-cad; T-cadherin
• UniProt Entry Name: CAD13_MOUSE

Uniprot Description

CDH13: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, GPI anchor

Cellular Component: extracellular space; neuron projection; focal adhesion; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; caveola; external side of plasma membrane

Molecular Function: adiponectin binding; protein binding; protein homodimerization activity; cadherin binding; metal ion binding; low-density lipoprotein binding; calcium ion binding

Biological Process: lamellipodium biogenesis; positive regulation of positive chemotaxis; positive regulation of smooth muscle cell proliferation; Rac protein signal transduction; positive regulation of calcium-mediated signaling; keratinocyte proliferation; negative regulation of cell adhesion; regulation of epidermal growth factor receptor signaling pathway; Rho protein signal transduction; low density lipoprotein mediated signaling; localization within membrane; negative regulation of cell proliferation; calcium-dependent cell-cell adhesion; regulation of endocytosis; endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; sprouting angiogenesis; regulation of cell growth; homophilic cell adhesion; positive regulation of cell-matrix adhesion; cell adhesion; positive regulation of cell migration