DNAJC30 recombinant protein

DNAJC30 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8121539

• Gene Names: DNAJC30; WBSCR18
• Purity: >95% as determined by SDS-PAGE
• Synonyms: DNAJC30; DNAJC30 Protein; Human; Recombinant (His Tag); Human DNAJC30 Protein (His Tag); WBSCR18 Protein; DnaJ (Hsp40) homolog; subfamily C; member 30; DNAJC30 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Ser39-Gly124

• Species: Human
• Predicted N Terminal: His
• Tag: N-His
• Protein Construction: A DNA sequence encoding the mature form of human DNAJC30 (Q96LL9)(Ser39-Gly124) was expressed with a polyhistide tag at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for DNAJC30 recombinant protein

Background: DNAJC30 is a member of the DNAJ molecular chaperone homology domain-containing protein family. DNAJC30 gene is deleted in williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. DNAJC30 is expressed in brain, heart, kidney, liver, lung, spleen, stomach and testis. It contains 1 J domain. DNAJC30 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

References

Hillier L W, et al. (2003) The DNA sequence of human chromosome 7. Nature. 424:157-164. Ota T, et al. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 36:40-5. Merla G, et al. (2002) Identification of additional transcripts in the Williams-Beuren syndrome critical region. Hum Genet. 110:429-38.

NCBI and Uniprot Product Information

• NCBI GI #: 119590064
• NCBI GeneID: 84277
• UniProt Accession #: Q96LL9; Q9BSG8
• Molecular Weight: 25,961 Da
• NCBI Official Full Name: Williams Beuren syndrome chromosome region 18
• NCBI Official Synonym Full Names: DnaJ (Hsp40) homolog, subfamily C, member 30
• NCBI Official Symbol: DNAJC30
• NCBI Official Synonym Symbols: WBSCR18
• NCBI Protein Information: dnaJ homolog subfamily C member 30; Williams Beuren syndrome chromosome region 18; williams-Beuren syndrome chromosomal region 18 protein
• UniProt Protein Name: DnaJ homolog subfamily C member 30
• Protein Family: DnaJ homolog subfamily
• UniProt Gene Name: DNAJC30
• UniProt Synonym Gene Names: WBSCR18
• UniProt Entry Name: DJC30_HUMAN

NCBI Description

This intronless gene encodes a member of the DNAJ molecular chaperone homology domain-containing protein family. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. [provided by RefSeq, Jul 2008]

Uniprot Description

Tissue specificity: Expressed in brain, heart, kidney, liver, lung, spleen, stomach and testis. Ref.1

Involvement in disease: DNAJC30 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Sequence similarities: Contains 1 J domain.