FKBP25/FKBP3 Recombinant Protein | FKBP3 recombinant protein

FKBP25/FKBP3 Protein, Human, Recombinant (GST Tag)

Cat. Num. AAA8121195

• Gene Names: FKBP3; FKBP-3; FKBP25; PPIase; FKBP-25
• Purity: >90% as determined by SDS-PAGE
• Synonyms: FKBP25/FKBP3; FKBP25/FKBP3 Protein; Human; Recombinant (GST Tag); Human FKBP3/FKBP25 Protein (GST Tag); FKBP-25 Protein; FKBP-3 Protein; FKBP25 Protein; PPIase Protein; FK506 binding protein 3; FKBP3 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile 50mM tris, 0.15M NaCl, 0.5mM GSH, pH8.0. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Ala2-Asp224

• Species: Human
• Predicted N Terminal: Met
• Tag: N-GST
• Protein Construction: A DNA sequence encoding the human FKBP3 (Q00688)(Ala 2-Asp 224) was fused with the GST tag at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for FKBP3 recombinant protein

Background: FKBP3 is a member of FK506-binding proteins (FKBPs). miR-145-5p overexpression suppressed cell proliferation of NSCLC cells which was abrogated by FKBP3 overexpression, that FKBP3/Sp1/HDAC2/p27 control cell proliferation during NSCLC development.

Product Categories/Family for FKBP3 recombinant protein

Phosphatases and Regulators

References

Wiederrecht G., et al., 1992, Biochem. Biophys. Res. Commun. 185: 298 - 303. Dephoure N., et al.,2008, Proc. Natl. Acad. Sci. USA.105:10762-7. Gauci S., et al., 2009, Anal. Chem. 81:4493-4501. Choudhary C., et al., 2009, Science. 325:834-840.

NCBI and Uniprot Product Information

• NCBI GI #: 206725536
• NCBI GeneID: 2287
• NCBI Accession #: NP_002004.1
• NCBI GenBank Nucleotide #: NM_002013
• UniProt Accession #: Q00688; Q14317; B2R4Q9
• Molecular Weight: 25,177 Da
• NCBI Official Full Name: Homo sapiens FK506 binding protein 3, 25kDa (FKBP3), mRNA
• NCBI Official Synonym Full Names: FK506 binding protein 3, 25kDa
• NCBI Official Symbol: FKBP3
• NCBI Official Synonym Symbols: FKBP-3; FKBP25; PPIase; FKBP-25
• NCBI Protein Information: peptidyl-prolyl cis-trans isomerase FKBP3; 25 kDa FK506-binding protein; 25 kDa FKBP; FK506-binding protein 25, T-cell; FK506-binding protein 3 (25kD); PPIase FKBP3; immunophilin FKBP25; rapamycin binding protein; rapamycin-selective 25 kDa immunophilin
• UniProt Protein Name: Peptidyl-prolyl cis-trans isomerase FKBP3
• Protein Family: FK506-binding protein
• UniProt Gene Name: FKBP3
• UniProt Synonym Gene Names: FKBP25; PPIase FKBP3; 25 kDa FKBP; FKBP-25; FKBP-3
• UniProt Entry Name: FKBP3_HUMAN

NCBI Description

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]

Uniprot Description

FKBP3: FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. Belongs to the FKBP-type PPIase family.

Protein type: EC 5.2.1.8; Isomerase

Chromosomal Location of Human Ortholog: 14q21.2

Cellular Component: endoplasmic reticulum membrane; nucleus

Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; receptor activity

Biological Process: protein peptidyl-prolyl isomerization