CLEC-1 Recombinant Protein | CLEC1A recombinant protein

CLEC-1 Protein, Human, Recombinant (hFc Tag)

Cat. Num. AAA8121103

• Gene Names: CLEC1A; CLEC1
• Purity: >95% as determined by SDS-PAGE
• Synonyms: CLEC-1; CLEC-1 Protein; Human; Recombinant (hFc Tag); Human CLEC1A/CLEC-1 Protein (Fc Tag); CLEC1 Protein; C-type lectin domain family 1; member A; CLEC1A recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Gln22-Asp280

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Glu
• Tag: N-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the human CLEC1A (NP_057595.2)(Gln22-Asp280) was expressed with the Fc region of human IgG1 at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for CLEC1A recombinant protein

Background: CLEC1A, also known as CLEC-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. CLEC1A contains 1 C-type lectin domain and is expressed preferentially in dendritic cells. It may play a role in regulating dendritic cell function. CLEC1A gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. Alternative splice variants have been described but their biological nature has not been determined. CLEC1A is found to be not only expressed in dendritic cells, but also in endothelial cells and in the latter aspect resembles the LOX-1 gene.

Product Categories/Family for CLEC1A recombinant protein

ITIM/ITAM Immunoreceptors and Related Molecules

References

Ebner S, et al. (2003) volutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. Proteins. 53(1):44-55.Strausberg RL, et al. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903.Drickamer K. (1999) C-type lectin-like domains. Curr Opin Struct Biol. 9(5):585-90.

NCBI and Uniprot Product Information

• NCBI GI #: 37577103
• NCBI GeneID: 51267
• NCBI Accession #: NP_057595.2
• NCBI GenBank Nucleotide #: NM_016511.2
• UniProt Accession #: Q8NC01; Q8IUW7; Q9NZH3
• Molecular Weight: 31,952 Da
• NCBI Official Full Name: C-type lectin domain family 1 member A
• NCBI Official Synonym Full Names: C-type lectin domain family 1, member A
• NCBI Official Symbol: CLEC1A
• NCBI Official Synonym Symbols: CLEC1
• NCBI Protein Information: C-type lectin domain family 1 member A; CLEC-1; C-type lectin-like receptor-1
• UniProt Protein Name: C-type lectin domain family 1 member A
• Protein Family: C-type lectin domain family
• UniProt Gene Name: CLEC1A
• UniProt Synonym Gene Names: CLEC1; CLEC-1
• UniProt Entry Name: CLC1A_HUMAN

NCBI Description

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. Alternative splice variants have been described but their biological nature has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]