Rabbit anti-Rat TIM-1/KIM-1 Polyclonal Antibody | anti-HAVCR1 antibody
Anti-TIM-1/KIM-1 Antibody, Rabbit Polyclonal
Gene Names
Havcr1; Kim1; KIM-1
Reactivity
Rat
Applications
ELISA
Purity
Protein A
Synonyms
TIM-1/KIM-1; Polyclonal Antibody; Anti-TIM-1/KIM-1 Antibody; Rabbit Polyclonal; KIM-1/TIM1/HACVR1 Antibody; Rabbit PAb; hepatitis A virus cellular receptor 1; anti-HAVCR1 antibody
Host
Rabbit
Reactivity
Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Rat KIM-1/TIM1/HACVR1
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-HAVCR1 antibody
ELISA (EIA)
Application Notes
ELISA: 1:1000-1:2000
This antibody can be used at 1:1000-1:2000 with the appropriate secondary reagents to detect Rat KIM1.
Optimal concentrations/dilutions should be determined by the end user.
This antibody can be used at 1:1000-1:2000 with the appropriate secondary reagents to detect Rat KIM1.
Optimal concentrations/dilutions should be determined by the end user.
Immunogen
Recombinant Rat KIM-1/TIM1/HAVCR1 Protein (Please inquire)
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with purified, recombinant Rat KIM-1/TIM1/HACVR1 (rR KIM-1/TIM1/HACVR1) (Please inquire). Total IgG was purified by Protein A affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-HAVCR1 antibody
HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulin mucin 1 (TIM-1), is a type of integral membrane glycoprotein. KIM-1 protein is widely expressed with the highest levels in the kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy, and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.
References
Tami C, et al. (2007) Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions. J Virol. 81(7): 3437-46.Rees AJ, et al. (2008) Kim-1/Tim-1: from biomarker to therapeutic target? Nephrol Dial Transplant. 23(11): 3394-6.Chaturvedi S, et al. (2009) Assay validation for KIM-1: human urinary renal dysfunction biomarker. Int J Biol Sci. 5(2): 128-34.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
hepatitis A virus cellular receptor 1 homolog
NCBI Official Synonym Full Names
hepatitis A virus cellular receptor 1
NCBI Official Symbol
Havcr1
NCBI Official Synonym Symbols
Kim1; KIM-1
NCBI Protein Information
hepatitis A virus cellular receptor 1 homolog
UniProt Protein Name
Hepatitis A virus cellular receptor 1 homolog
Protein Family
UniProt Gene Name
Havcr1
UniProt Synonym Gene Names
Kim1; HAVcr-1; KIM-1; TIMD-1
UniProt Entry Name
HAVR1_RAT
NCBI Description
may be a member of the mucosal addressin cell adhesion molecule family; may be involved in restoration of the morphological integrity and function to postischemic kidney [RGD, Feb 2006]
Uniprot Description
May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair ().
Research Articles on HAVCR1
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Product Notes
The HAVCR1 havcr1 (Catalog #AAA8112569) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TIM-1/KIM-1 Antibody, Rabbit Polyclonal reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TIM-1/KIM-1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 1:1000-1:2000 This antibody can be used at 1:1000-1:2000 with the appropriate secondary reagents to detect Rat KIM1. Optimal concentrations/dilutions should be determined by the end user. Researchers should empirically determine the suitability of the HAVCR1 havcr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TIM-1/KIM-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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