SDS-PAGE
KIM-1 / TIM1 / HACVR1 recombinant protein
Recombinant Rat KIM-1 / TIM1 / HACVR1 Protein (His & Fc tag)
Gene Names
Havcr1; Kim1; KIM-1
Purity
> 93 % as determined by SDS-PAGE
Synonyms
KIM-1 / TIM1 / HACVR1; Recombinant Rat KIM-1 / TIM1 / HACVR1 Protein (His & Fc tag); KIM-1; Kim1; Havcr1; KIM-1 / TIM1 / HACVR1 recombinant protein
Host
Human Cells
Purity/Purification
> 93 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
307
Application Notes
The recombinant rat HAVCR1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 468 amino acids and predicts a molecular mass of 52.6 kDa. As a result of glycosylation, the apparent molecular mass of the rat HAVCR1/Fc monomer is approximately 90-100 kDa in SDS-PAGE under reducing conditions.
Predicted N Terminal
Glu 20
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for KIM-1 / TIM1 / HACVR1 recombinant protein
Background: Human HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type I integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.
Description: A DNA sequence encoding the extracellular domain of rat HAVCR1 (NP_775172.1) (Ser 18-Val 238) was fused with a polyhistidine tag at the C-terminus and the Fc region of human IgG1 at the N-terminus.
Description: A DNA sequence encoding the extracellular domain of rat HAVCR1 (NP_775172.1) (Ser 18-Val 238) was fused with a polyhistidine tag at the C-terminus and the Fc region of human IgG1 at the N-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
33,964 Da
NCBI Official Full Name
hepatitis A virus cellular receptor 1 homolog
NCBI Official Synonym Full Names
hepatitis A virus cellular receptor 1
NCBI Official Symbol
Havcr1
NCBI Official Synonym Symbols
Kim1; KIM-1
NCBI Protein Information
hepatitis A virus cellular receptor 1 homolog
UniProt Protein Name
Hepatitis A virus cellular receptor 1 homolog
UniProt Gene Name
Havcr1
UniProt Synonym Gene Names
Kim1; HAVcr-1; KIM-1; TIMD-1
NCBI Description
may be a member of the mucosal addressin cell adhesion molecule family; may be involved in restoration of the morphological integrity and function to postischemic kidney [RGD, Feb 2006]
Uniprot Description
May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair ().
Research Articles on KIM-1 / TIM1 / HACVR1
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Product Notes
The KIM-1 / TIM1 / HACVR1 havcr1 (Catalog #AAA2547510) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant rat HAVCR1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 468 amino acids and predicts a molecular mass of 52.6 kDa. As a result of glycosylation, the apparent molecular mass of the rat HAVCR1/Fc monomer is approximately 90-100 kDa in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the KIM-1 / TIM1 / HACVR1 havcr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KIM-1 / TIM1 / HACVR1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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