Rabbit anti-Mouse TFPI2 Monoclonal Antibody | anti-TFPI2 antibody
Recombinant Anti-TFPI2 Antibody, Rabbit Monoclonal
Gene Names
Tfpi2; AV000670; PP5/TFPI-2
Reactivity
Mouse
Applications
ELISA, ELISA
Purity
Protein A
Synonyms
TFPI2; Monoclonal Antibody; Recombinant Anti-TFPI2 Antibody; Rabbit Monoclonal; TFPI2 Antibody; Rabbit MAb; tissue factor pathway inhibitor 2; Anti-AV000670 Antibody; Anti-PP5/TFPI-2 Antibody; anti-TFPI2 antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
101
Specificity
Mouse TFPI2.
Has cross-reactivity in ELISA with Human TFPI2
Has cross-reactivity in ELISA with Human TFPI2
Has cross-reactivity in ELISA with Human TFPI2
Has cross-reactivity in ELISA with Human TFPI2
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-TFPI2 antibody
ELISA (EIA), ELISA (EIA) (Cap)
Application Notes
ELISA: 1:5000-1:10,000
ELISA (Cap): 1:250-1:2000
ELISA (Cap): This antibody will detect Mouse TFPI2 in ELISA pair set.
In a sandwich ELISA, it can be used as capture antibody.
ELISA (Cap): 1:250-1:2000
ELISA (Cap): This antibody will detect Mouse TFPI2 in ELISA pair set.
In a sandwich ELISA, it can be used as capture antibody.
Antibody Type
Recombinant Antibody
Immunogen
Recombinant Mouse TFPI2 protein
Conjugation
Unconjugated
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse TFPI2 (rM TFPI2).
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-TFPI2 antibody
Tissue factor pathway inhibitor-2 (TFPI2), a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). It is a 32 kDa matrix-associated glycoprotein consisting of a short amino-terminal region, three tandem Kunitz-type domains and a positively charged carboxy-terminal tail. TFPI2 inhibits plasmin-dependent activation of several metalloproteinases. TFPI2 is highly abundant in the full-term placenta and widely expressed in various adult human tissues, such as the liver, skeletal muscle, heart, kidney, and pancreas. The expression of TFPI2 in tumors is inversely related to an increasing degree of malignancy, which may suggest a role for TFPI2 in the maintenance of tumor stability and inhibition of the growth of neoplasms. TFPI2 inhibits the tissue factor/factor VIIa (TF/VIIa) complex and a wide variety of serine proteinases including plasmin, plasma kallikrein, factor XIa, trypsin, and chymotrypsin. TFPI2 is involved in regulating pericellular proteases implicated in a variety of physiologic and pathologic processes including cancer cell invasion, vascular inflammation, and atherosclerosis. TFPI2 has also been shown to induce apoptosis and inhibit angiogenesis, which may contribute significantly to tumor growth inhibition.
Product Categories/Family for anti-TFPI2 antibody
References
Peerschke EI, et al. (2004) Tissue factor pathway inhibitor-2 (TFPI-2) recognizes the complement and kininogen binding protein gC1qR/p33 (gC1qR): implications for vascular inflammation. Thromb Haemost. 92(4): 811-9.Rollin J, et al. (2005) Expression and methylation status of tissue factor pathway inhibitor-2 gene in non-small-cell lung cancer. Br J Cancer. 92(4): 775-83.Chand HS, et al. (2005) Structure, function and biology of tissue factor pathway inhibitor-2. Thromb Haemost. 94(6): 1122-30.Sierko E, et al. (2007) The role of tissue factor pathway inhibitor-2 in cancer biology. Semin Thromb Hemost. 33(7): 653-9.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
26,137 Da
NCBI Official Full Name
tissue factor pathway inhibitor 2
NCBI Official Synonym Full Names
tissue factor pathway inhibitor 2
NCBI Official Symbol
Tfpi2
NCBI Official Synonym Symbols
AV000670; PP5/TFPI-2
NCBI Protein Information
tissue factor pathway inhibitor 2
UniProt Protein Name
Tissue factor pathway inhibitor 2
Protein Family
UniProt Gene Name
Tfpi2
UniProt Synonym Gene Names
TFPI-2
UniProt Entry Name
TFPI2_MOUSE
Uniprot Description
TFPI2: May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: extracellular region; nucleus
Molecular Function: protease inhibitor activity; serine-type endopeptidase inhibitor activity
Biological Process: blood coagulation; hemostasis; negative regulation of peptidase activity
Research Articles on TFPI2
Similar Products
Product Notes
The TFPI2 tfpi2 (Catalog #AAA8112239) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Anti-TFPI2 Antibody, Rabbit Monoclonal reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TFPI2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), ELISA (EIA) (Cap). ELISA: 1:5000-1:10,000 ELISA (Cap): 1:250-1:2000 ELISA (Cap): This antibody will detect Mouse TFPI2 in ELISA pair set. In a sandwich ELISA, it can be used as capture antibody. Researchers should empirically determine the suitability of the TFPI2 tfpi2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TFPI2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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