Human I-TAC ELISA Kit | I-TAC elisa kit

I-TAC (Human) OmniKine ELISA Kit

Cat. Num. AAA9501872

• Gene Names: CXCL11; IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B
• Reactivity: Human
• Synonyms: I-TAC; I-TAC (Human) OmniKine ELISA Kit; C-X-C motif chemokine 11; Beta-R1; H174; Interferon gamma-inducible protein 9; Interferon-inducible T-cell alpha chemoattractant; Small-inducible cytokine B11; SCYB11; SCYB9B; I-TAC elisa kit

• Reactivity: Human
• Specificity: The OmniKine Human I-TAC ELISA is capable of recognizing both recombinant and naturally produced Human I-TAC proteins. The antigens listed below were tested at 50 ng/ml and exhibited less than 1% cross reactivity.; Murine: I-TAC; The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross reactivity or interference.; Human: ENA-78, IL-2, IL-8 (72 aa), IL-8 (77 aa), IP-10, MIG, NAP-2
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 106

• Samples: Plasma, serum, lysate
• Assay Type: Sandwich ELISA
• Detection Range: 32-2000 pg/ml
• Sensitivity: 32-2000 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Human I-TAC ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human I-TAC proteins within the range of 32-2000 pg/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 693074655
• NCBI GeneID: 6373
• NCBI Accession #: NP_001289052.1
• NCBI GenBank Nucleotide #: NM_001302123.1
• UniProt Accession #: O14625; Q53YA3; Q92840
• Molecular Weight: 10,365 Da
• NCBI Official Full Name: C-X-C motif chemokine 11 isoform 2
• NCBI Official Synonym Full Names: C-X-C motif chemokine ligand 11
• NCBI Official Symbol: CXCL11
• NCBI Official Synonym Symbols: IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B
• NCBI Protein Information: C-X-C motif chemokine 11
• UniProt Protein Name: C-X-C motif chemokine 11
• UniProt Gene Name: CXCL11
• UniProt Synonym Gene Names: ITAC; SCYB11; SCYB9B; IP-9; I-TAC

NCBI Description

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

Uniprot Description

CXCL11: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21.1

Cellular Component: cell; extracellular region; extracellular space

Molecular Function: chemokine activity; CXCR3 chemokine receptor binding; heparin binding; protein binding

Biological Process: cell-cell signaling; chemotaxis; G-protein coupled receptor signaling pathway; immune response; inflammatory response; positive regulation of cAMP metabolic process; positive regulation of leukocyte chemotaxis; positive regulation of release of sequestered calcium ion into cytosol; regulation of cell proliferation; response to lipopolysaccharide; signal transduction