Rabbit anti-Mouse Syndecan-1/CD138 Polyclonal Antibody | anti-SDC1 antibody
Anti-Syndecan-1/CD138 Antibody, Rabbit Polyclonal
Gene Names
Sdc1; Sstn; Synd; CD138; Synd1; syn-1; AA408134; AA409076
Reactivity
Mouse
Applications
ELISA
Purity
Protein A
Synonyms
Syndecan-1/CD138; Polyclonal Antibody; Anti-Syndecan-1/CD138 Antibody; Rabbit Polyclonal; Syndecan-1/SDC1/CD138 Antibody; Rabbit PAb; syndecan 1; Anti-AA408134 Antibody; Anti-AA409076 Antibody; Anti-CD138 Antibody; Anti-Sstn Antibody; Anti-syn-1 Antibody; Anti-Synd Antibody; Anti-Synd1 Antibody; anti-SDC1 antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Mouse Syndecan-1/SDC1/CD138
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-SDC1 antibody
ELISA (EIA)
Application Notes
ELISA: 1:1000-1:2000
Immunogen
Recombinant Mouse Syndecan-1/SDC1/CD138 protein
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with purified, recombinant Mouse Syndecan-1/SDC1/CD138. Total IgG was purified by Protein A affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-SDC1 antibody
Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.
References
Inki P, et al. (1996) The role of syndecan-1 in malignancies. Ann Med. 28(1): 63-7.Subramanian SV, et al. (1997) Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J Biol Chem. 272(23): 14713-20.Park PW, et al. (2001) Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Nature. 411(6833): 98-102.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
28,235 Da
NCBI Official Full Name
syndecan-1
NCBI Official Synonym Full Names
syndecan 1
NCBI Official Symbol
Sdc1
NCBI Official Synonym Symbols
Sstn; Synd; CD138; Synd1; syn-1; AA408134; AA409076
NCBI Protein Information
syndecan-1
UniProt Protein Name
Syndecan-1
Protein Family
UniProt Gene Name
Sdc1
UniProt Synonym Gene Names
Synd-1; Synd1; SYND1
Uniprot Description
syndecan-1: Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Belongs to the syndecan proteoglycan family.
Protein type: Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12 A1.1|12 3.94 cM
Cellular Component: cell surface; cytoplasm; external side of plasma membrane; focal adhesion; protein complex
Molecular Function: glycoprotein binding; protein C-terminus binding
Biological Process: cell migration; inflammatory response; myoblast development; Wnt receptor signaling pathway through beta-catenin
Research Articles on SDC1
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Product Notes
The SDC1 sdc1 (Catalog #AAA8111864) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Syndecan-1/CD138 Antibody, Rabbit Polyclonal reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Syndecan-1/CD138 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 1:1000-1:2000. Researchers should empirically determine the suitability of the SDC1 sdc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Syndecan-1/CD138, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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