Syndecan-1/CD138 Recombinant Protein | SDC1 recombinant protein

Syndecan-1/CD138 Protein, Mouse, Recombinant (His Tag)

Cat. Num. AAA8122886

• Gene Names: Sdc1; Sstn; Synd; CD138; Synd1; syn-1; AA408134; AA409076
• Purity: >80% as determined by SDS-PAGE
• Synonyms: Syndecan-1/CD138; Syndecan-1/CD138 Protein; Mouse; Recombinant (His Tag); Mouse Syndecan-1/SDC1/CD138 Protein (His Tag); AA408134 Protein; AA409076 Protein; CD138 Protein; Sstn Protein; syn-1 Protein; Synd Protein; Synd1 Protein; syndecan 1; SDC1 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >80% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Glu252

• Species: Mouse
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Gln 17
• Tag: C-His
• Protein Construction: A DNA sequence encoding the extracellular domain of mouse SDC1 (NP_035649.1)(Met 1-Glu 252) was expressed, with a C-terminal polyhistidine tag.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

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Related Product Information for SDC1 recombinant protein

Background: Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.

References

Inki P, et al. (1996) The role of syndecan-1 in malignancies. Ann Med. 28(1): 63-7.Subramanian SV, et al. (1997) Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J Biol Chem. 272(23): 14713-20.Park PW, et al. (2001) Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Nature. 411(6833): 98-102.

NCBI and Uniprot Product Information

• NCBI GI #: 6755438
• NCBI GeneID: 20969
• NCBI Accession #: NP_035649.1
• NCBI GenBank Nucleotide #: NM_011519.2
• UniProt Accession #: P18828; Q62278; Q9WVD2
• Molecular Weight: 28,235 Da
• NCBI Official Full Name: syndecan-1
• NCBI Official Synonym Full Names: syndecan 1
• NCBI Official Symbol: Sdc1
• NCBI Official Synonym Symbols: Sstn; Synd; CD138; Synd1; syn-1; AA408134; AA409076
• NCBI Protein Information: syndecan-1
• UniProt Protein Name: Syndecan-1
• Protein Family: Syndecan
• UniProt Gene Name: Sdc1
• UniProt Synonym Gene Names: Synd-1; Synd1; SYND1

Uniprot Description

syndecan-1: Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Belongs to the syndecan proteoglycan family.

Protein type: Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12 A1.1|12 3.94 cM

Cellular Component: cell surface; cytoplasm; external side of plasma membrane; focal adhesion; protein complex

Molecular Function: glycoprotein binding; protein C-terminus binding

Biological Process: cell migration; inflammatory response; myoblast development; Wnt receptor signaling pathway through beta-catenin