Immunohistochemistry (IHC)
(Immunochemical staining of human MGST1 in human liver with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human MGST1 Polyclonal Antibody | anti-MGST1 antibody
Anti-MGST1 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
MGST1; Polyclonal Antibody; Anti-MGST1 Antibody; Rabbit Polyclonal; MGST1/Microsomal glutathione S-transferase 1 Antibody; Rabbit PAb; Antigen Affinity Purified; microsomal glutathione S-transferase 1; Anti-GST12 Antibody; Anti-MGST Antibody; Anti-MGST-I Antibody; anti-MGST1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human MGST1/Microsomal glutathione S-transferase 1
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-MGST1 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
E Coli-derived Human MGST1/Microsomal glutathione S-transferase 1 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human MGST1/Microsomal glutathione S-transferase 1 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human MGST1 in human liver with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human MGST1 in human liver with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-MGST1 antibody
Microsomal glutathione transferase (MGST1, EC 2.5.1.18) is a membrane-bound glutathione transferase extensively studied for its ability to detoxify reactive intermediates, including metabolic electrophile intermediates and lipophilic hydroperoxides through its glutathione-dependent transferase and peroxidase activities. MGST1 belongs to a superfamily named MAPEG (membrane-associated proteins in eicosanoid and glutathione metabolism). It is expressed in high amounts in the liver, located both in the endoplasmic reticulum and the inner and outer mitochondrial membranes. Microsomal glutathione S-transferase 1 (MGST1) plays a vital role in oxidative stress, tumor occurrence, and drug resistance. The MGST1 gene has two alternative first exons and is located in the 12p13.1-13.2 region. Two other potential first exons were determined to be nonfunctional. The region between the functional first exons cannot direct transcription.
References
Shimoji M, et al. (2017) Molecular basis for the dual subcellular distribution of microsomal glutathione transferase 1. Biochim Biophys Acta Biomembr 1859 (2): 238-244.
Schaffert CS (2011) Role of mgst1 in reactive intermediate-induced injury. World J Gastroenterol 17 (20): 2552-2557.
Morgenstern R, et al. (2011) Microsomal glutathione transferase 1: Mechanism and functional roles. Drug Metab Rev 43 (2): 300-306.Kelner MJ, et al. (2000) Structural organization of the microsomal glutathione s-transferase gene (mgst1) on chromosome 12p13.1-13.2. Identification of the correct promoter region and demonstration of transcriptional regulation in response to oxidative stress. J Biol Chem 275 (17): 13000-13006.
Schaffert CS (2011) Role of mgst1 in reactive intermediate-induced injury. World J Gastroenterol 17 (20): 2552-2557.
Morgenstern R, et al. (2011) Microsomal glutathione transferase 1: Mechanism and functional roles. Drug Metab Rev 43 (2): 300-306.Kelner MJ, et al. (2000) Structural organization of the microsomal glutathione s-transferase gene (mgst1) on chromosome 12p13.1-13.2. Identification of the correct promoter region and demonstration of transcriptional regulation in response to oxidative stress. J Biol Chem 275 (17): 13000-13006.
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Product Notes
The MGST1 (Catalog #AAA8108648) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-MGST1 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MGST1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the MGST1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MGST1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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