Mouse anti-Human MCP3 Monoclonal Antibody | anti-CCL7 antibody

Anti-MCP3 Antibody (PE), Mouse Monoclonal

Cat. Num. AAA8105973

• Gene Names: CCL7; FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Purity: Protein A
• Synonyms: MCP3; Monoclonal Antibody; Anti-MCP3 Antibody (PE); Mouse Monoclonal; MCP-3/CCL7 Antibody (PE); Mouse MAb; chemokine (C-C motif) ligand 7; Anti-FIC Antibody; Anti-MARC Antibody; Anti-MCP-3 Antibody; Anti-MCP3 Antibody; Anti-NC28 Antibody; Anti-SCYA6 Antibody; Anti-SCYA7 Antibody; anti-CCL7 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse IgG1
• Clone Number: 18
• Specificity: Human MCP-3/CCL7
• Purity/Purification: Protein A
• Form/Format: Liquid; Aqueous solution containing 0.5% BSA and 0.09% sodium azide
• Concentration: 10ul/Test, 0.1mg/ml (varies by lot)

• Applicable Applications for anti-CCL7 antibody: Flow Cytometry (FC/FACS/FCM)
• Immunogen: Recombinant Human MCP-3/CCL7 protein
• Conjugation: PE
• Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human MCP-3/CCL7 (rh MCP-3/CCL7) and conjugated with PE under optimum conditions, the unreacted PE was removed.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Flow Cytometry (FC/FACS)

(Flow cytometric analysis of Human CCL7 expression on THP1 cells. The cells were treated according to manufacturer's manual (BD Pharmingen'), and then stained with PE-conjugated anti-Human CCL7. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.)

Related Product Information for anti-CCL7 antibody

Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokine ligand 7(CCL7), also known as MCP-3, is a isform of the C-C chemokine subfamily of the chemokine family which is produced by certain tumor cells and by macrophages. It also own two adjacent N-terminal cysteine residues. Chemokine ligand 7(CCL7) spacifically attracts monocytes, and regulates macrophage function.

Product Categories/Family for anti-CCL7 antibody

IL17 signaling pathway

References

Laing KJ, et al. (2004) Chemokines. Developmental and comparative immunology. 28(5): 443-60.Cocchi F, et al. (1995) Identification of RANTES, MIP-1a, and MIP-1b as the major HIV-suppressive factor produced by CD8+ T cells. Science. 270 (5243): 1811-5.Michalec L, et al. (2002) CCL7 and CXCL10 Orchestrate Oxidative Stress-Induced Neutrophilic Lung Inflammation. The Journal of Immunology. 168: 846-52.Wetzel K, et al. (2007) MCP-3 (CCL7) delivered by parvovirus MVMp reduces tumorigenicity of mouse melanoma cells through activation of T lymphocytes and NK cells.International Journal of Cancer. 120(6):1364-71.

NCBI and Uniprot Product Information

• NCBI GI #: 13435402
• NCBI GeneID: 6354
• NCBI Accession #: NP_006264.2
• NCBI GenBank Nucleotide #: NM_006273.3
• Molecular Weight: 11,200 Da
• NCBI Official Full Name: C-C motif chemokine 7
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 7
• NCBI Official Symbol: CCL7
• NCBI Official Synonym Symbols: FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7
• NCBI Protein Information: C-C motif chemokine 7; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; small inducible cytokine A7 (monocyte chemotactic protein 3); small-inducible cytokine A7
• Protein Family: C-C motif chemokine

NCBI Description

This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]