Rabbit BVES Polyclonal Antibody | anti-BVES antibody

Anti-BVES Antibody, Rabbit Polyclonal

Cat. Num. AAA8103451

• Gene Names: Bves; Pop1; mBVES; Popdc1
• Reactivity: Mouse; Predicted to React with: Rat (Species predicted to react based on 100% sequence homology)
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: BVES; Polyclonal Antibody; Anti-BVES Antibody; Rabbit Polyclonal; BVES Antibody; Rabbit PAb; Antigen Affinity Purified; blood vessel epicardial substance; Anti-mBVES Antibody; Anti-Pop1 Antibody; Anti-Popdc1 Antibody; anti-BVES antibody

• Host: Rabbit
• Reactivity: Mouse; Predicted to React with: Rat (Species predicted to react based on 100% sequence homology)
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Mouse BVES
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-BVES antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:100-1:500
• Immunogen: A synthetic peptide corresponding to the center region of the Mouse BVES
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Mouse BVES, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of mouse BVES in mouse heart with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-BVES antibody

Blood vessel epicardial substance (BVES), or POPDC1, is a tight junction-associated transmembrane protein that modulates epithelial-to-mesenchymal transition (EMT) via junctional signaling pathways. BVES plays a protective role both in ulcerative and infectious colitis and identify BVES as a critical protector of colonic mucosal integrity. The Popeye domain containing1, also called Bves (Popdc1/Bves), is a transmembrane protein that functions in muscle regeneration, heart rate regulation, hypoxia tolerance, and ischemia preconditioning. The expression of Popdc1/Bves is elevated in cardiomyocytes maintained in serum free defined medium. Popdc1/Bves plays a role in the preservation of cardiomyocyte viability under serum deficiency through the alteration of Rac1 activity and the regulation of Bnip3 expression by FoxO3 and NFkappaB transcription factors pointing to Popdc1/Bves as a potential target to enhance heart protection. Blood vessel epicardial substance (BVES) is a tight junction-associated protein that regulates epithelial-mesenchymal states and is underexpressed in epithelial malignancy. Loss of BVES promotes inflammatory tumourigenesis through dysregulation of Wnt signalling and the oncogene c-Myc. BVES promoter methylation status may serve as a CAC biomarker. Blood vessel epicardial substance (BVES/Popdc1) is a junctional-associated transmembrane protein that is underexpressed in a number of malignancies and regulates epithelial-to-mesenchymal transition. BVES is a key regulator of intestinal stem cell programs and mucosal homeostasis.

NCBI and Uniprot Product Information

• NCBI GI #: 13195598
• NCBI GeneID: 23828
• NCBI Accession #: NP_077247.1
• NCBI GenBank Nucleotide #: NM_024285.2
• UniProt Accession #: Q9ES83; Q8C8L3; A2RS91
• Molecular Weight: 41,016 Da
• NCBI Official Full Name: blood vessel epicardial substance
• NCBI Official Synonym Full Names: blood vessel epicardial substance
• NCBI Official Symbol: Bves
• NCBI Official Synonym Symbols: Pop1; mBVES; Popdc1
• NCBI Protein Information: blood vessel epicardial substance
• UniProt Protein Name: Blood vessel epicardial substance
• Protein Family: Blood vessel epicardial substance
• UniProt Gene Name: Bves
• UniProt Synonym Gene Names: mBVES; Popeye protein 1

Uniprot Description

BVES: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3- mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading. Belongs to the popeye family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 10 B2|10 23.47 cM

Cellular Component: bicellular tight junction; caveola; cell junction; cell projection membrane; integral component of membrane; lateral plasma membrane; membrane; plasma membrane; sarcolemma

Molecular Function: cAMP binding; nucleotide binding; protein binding; structural molecule activity

Biological Process: cell adhesion; heart development; hemopoietic progenitor cell differentiation; multicellular organism development; positive regulation of locomotion; positive regulation of receptor recycling; regulation of cell shape; regulation of GTPase activity; regulation of heart rate; regulation of membrane potential; skeletal muscle tissue development; vesicle docking; vesicle-mediated transport