Immunohistochemistry (IHC)
(Immunochemical staining of mouse Sfrp1 in mouse testis with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Mouse SFRP1 Polyclonal Antibody | anti-SFRP1 antibody
Anti-SFRP1 Antibody, Rabbit Polyclonal
Gene Names
Sfrp1; sFRP-1; AW011917; AW107218; AW742929; 2210415K03Rik
Reactivity
Mouse
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
SFRP1; Polyclonal Antibody; Anti-SFRP1 Antibody; Rabbit Polyclonal; SFRP1 Antibody; Rabbit PAb; Antigen Affinity Purified; secreted frizzled-related protein 1; Anti-2210415K03Rik Antibody; Anti-AW011917 Antibody; Anti-AW107218 Antibody; Anti-AW742929 Antibody; Anti-sFRP-1 Antibody; anti-SFRP1 antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Mouse SFRP1
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-SFRP1 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:200-1:1000
Immunogen
A synthetic peptide corresponding to the center region of the Mouse SFRP1
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Mouse SFRP1, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of mouse Sfrp1 in mouse testis with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of mouse Sfrp1 in mouse testis with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of mouse Sfrp1 in mouse heart with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of mouse Sfrp1 in mouse heart with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-SFRP1 antibody
Secreted frizzled-related protein 1, also known as sFRP1, is a 35 kDa prototypical member of the SFRP family. SFRP family consists of five secreted glycoproteins in humans acting as extracellular signaling ligands. Each is approximately 3 amino acids in length and contains a cysteine-rich domain (CRD) that shares 3-5% sequence homology with the CRD of Frizzled (Fz) receptors, a putative signal sequence, and a conserved hydrophilic carboxy-terminal domain. SFRPs act as soluble modulators of Wnt signaling, counteracting Wnt-induced effects at high concentrations and promoting them at lower concentrations. SFRPs are able to bind Wnt proteins and Fz receptors in the extracellular compartment. The interaction between SFRPs and Wnt proteins prevents the latter from binding the Fz receptors. The Wnt pathway plays a key role in embryonic development, cell differentiation and cell proliferation. The deregulation of this critical developmental pathway occurs in several human tumor entities. Mouse sFRP1 is highly expressed in kidney and embryonic heart, as well as in the eye, where it is principally localized to the ciliary body and the lens epithelium.
References
Finch P.W., et al., (1997), Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. Proc. Natl. Acad. Sci. U.S.A. 94:6770-6775.Melkonyan H.S., et al., (1997), SARPs: a family of secreted apoptosis-related proteins.Proc. Natl. Acad. Sci. U.S.A. 94:13636-13641.Zhou Z., et al., (1998), Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors.Int. J. Cancer 78:95-99.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
35,413 Da
NCBI Official Full Name
secreted frizzled-related protein 1
NCBI Official Synonym Full Names
secreted frizzled-related protein 1
NCBI Official Symbol
Sfrp1
NCBI Official Synonym Symbols
sFRP-1; AW011917; AW107218; AW742929; 2210415K03Rik
NCBI Protein Information
secreted frizzled-related protein 1; secreted frizzled-related sequence protein 1
UniProt Protein Name
Secreted frizzled-related protein 1
Protein Family
UniProt Gene Name
Sfrp1
UniProt Synonym Gene Names
sFRP-1
UniProt Entry Name
SFRP1_MOUSE
Similar Products
Product Notes
The SFRP1 sfrp1 (Catalog #AAA8103412) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-SFRP1 Antibody, Rabbit Polyclonal reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SFRP1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:200-1:1000. Researchers should empirically determine the suitability of the SFRP1 sfrp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SFRP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
