Mouse anti-Human CD204/MSR1 Monoclonal Antibody | anti-MSR1 antibody

Anti-CD204/MSR1 Antibody, Mouse Monoclonal

Cat. Num. AAA8102763

• Gene Names: MSR1; SRA; SR-A; CD204; phSR1; phSR2; SCARA1
• Reactivity: Human
• Applications: ELISA
• Purity: Protein A
• Synonyms: CD204/MSR1; Monoclonal Antibody; Anti-CD204/MSR1 Antibody; Mouse Monoclonal; MSR1/CD204 Antibody; Mouse MAb; macrophage scavenger receptor 1; Anti-CD204 Antibody; Anti-phSR1 Antibody; Anti-phSR2 Antibody; Anti-SCARA1 Antibody; Anti-SR-A Antibody; Anti-SRA Antibody; anti-MSR1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Clone Number: 03
• Specificity: Human MSR1/CD204
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-MSR1 antibody: ELISA (EIA) (Cap)
• Application Notes: ELISA (Cap): This antibody will detect Human MSR1/CD204 in ELISA pair set.; In a sandwich ELISA, it can be used as capture antibody when paired with.
• Immunogen: Recombinant Human MSR1/CD204 Protein
• Conjugation: Unconjugated
• Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human MSR1/CD204 (rh MSR1/CD204). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-MSR1 antibody

Macrophage scavenger receptor types I and II, also known as Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD24, MSR1, and SCARA1, is a single-pass type II membrane protein that contains one collagen-like domain and one SRCR domain. Macrophages are distributed in all peripheral tissues and play a critical role in the first line of the innate immune defenses against bacterial infection by phagocytosis of bacterial pathogens through the macrophage scavenger receptor 1 (MSR1). MSR1/SCARA1 is one of the membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low-density lipoproteins (LDL). MSR1/SCARA1 is also involved in chronic inflammation which is a risk factor for prostate cancer. MSR1 1 gene was identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer.

References

Wang L. et al., 2003, Nat Genet. 35 (2): 128-9. Chen Y.C. et al., 2008, Cancer Epidemiol Biomarkers Prev. 17 (4): 1001-3. Shirato K. et al., 2009, Pflugers Arch. 459 (1): 93-103. Sun J. et al., 2006, Prostate. 66 (7): 728-37.

NCBI and Uniprot Product Information

• NCBI GI #: 20357512
• NCBI GeneID: 4481
• NCBI Accession #: NP_619729.1
• NCBI GenBank Nucleotide #: NM_138715.2
• UniProt Accession #: P21757; O60505; P21759; Q45F10; D3DSP3
• Molecular Weight: 49,762 Da
• NCBI Official Full Name: macrophage scavenger receptor types I and II isoform type 1
• NCBI Official Synonym Full Names: macrophage scavenger receptor 1
• NCBI Official Symbol: MSR1
• NCBI Official Synonym Symbols: SRA; SR-A; CD204; phSR1; phSR2; SCARA1
• NCBI Protein Information: macrophage scavenger receptor types I and II; scavenger receptor class A member 1; scavenger receptor class A, member 1; macrophage scavenger receptor type III; macrophage acetylated LDL receptor I and II
• UniProt Protein Name: Macrophage scavenger receptor types I and II
• Protein Family: Macrophage scavenger receptor
• UniProt Gene Name: MSR1
• UniProt Synonym Gene Names: SCARA1
• UniProt Entry Name: MSRE_HUMAN

NCBI Description

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]

Uniprot Description

MSR1: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize actetylated LDL. Defects in MSR1 may be a cause of prostate cancer (PC). A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet- ring cell carcinoma and neuroendocrine carcinoma. MSR1 variants may play a role in susceptibility to prostate cancer. MSR1 variants have been found in individuals with prostate cancer and co-segregate with the disease in some families. Defects in MSR1 may be a cause of Barrett esophagus (BE). A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Genetic variants in MSR1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: collagen; integral to plasma membrane; plasma membrane; cytosol

Molecular Function: protein binding; low-density lipoprotein binding; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; cholesterol transport; lipoprotein transport

Disease: Prostate Cancer; Barrett Esophagus