Rabbit anti-Human IL18RAP Monoclonal Antibody | anti-IL18RAP antibody

Recombinant Anti-IL18RAP Antibody, Rabbit Monoclonal

Cat. Num. AAA8101517

• Gene Names: IL18RAP; ACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Protein A
• Synonyms: IL18RAP; Monoclonal Antibody; Recombinant Anti-IL18RAP Antibody; Rabbit Monoclonal; IL18RAP/IL1R7 Antibody; Rabbit MAb; interleukin 18 receptor accessory protein; Anti-ACPL Antibody; Anti-CD218b Antibody; Anti-CDw218b Antibody; Anti-IL-18R-beta Antibody; Anti-IL-18RAcP Antibody; Anti-IL-18Rbeta Antibody; Anti-IL-1R-7 Antibody; Anti-IL-1R7 Antibody; Anti-IL-1RAcPL Antibody; Anti-IL18RB Antibody; anti-IL18RAP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone Number: 290
• Specificity: Human IL18RAP/IL1R7
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-IL18RAP antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000; ELISA: 1:5000-1:10,000
• Antibody Type: Recombinant Antibody
• Immunogen: Recombinant Human IL18RAP/IL1R7 Protein
• Conjugation: Unconjugated
• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human IL18RAP/IL1R7 (rh IL18RAP/IL1R7).
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Western Blot (WB)

(Anti-IL1R7 rabbit monoclonal antibody at 1:500 dilution Lane A: RAW264.7 Whole Cell Lysate Lane B: K562 Whole Cell Lysate Lysates/proteins at 30 ug per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:68 kDa Observed band size:75 kDa)

Related Product Information for anti-IL18RAP antibody

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand-binding subunit of the IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. IL18RAP is required for the high-affinity binding of interleukin 18 (IL-18) to its receptor complex. IL18RAP together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Two putative isoforms of IL18RAP were detected and the ratios and total levels of these isoforms may contribute to the etiology of coeliac disease. IL18R1 and IL18RAP polymorphisms have been found associated with diseases such as schizophrenia, HSV1 seropositivity, and atopic asthma. Analysis of IL18R1 and IL18RAP SNPs in 5 European prospective cohorts suggests that the variability of these genes are unlikely to contribute to modulate the risk of CVD in European populations.

Product Categories/Family for anti-IL18RAP antibody

Neuroinflammation; IL1 signaling pathway

References

Zhernakova A, et al.. (2008) Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. Am J Hum Genet. 82(5): 1202-10.Grisoni ML, et al.. (2009) Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. BMC Med Genet. 10: 44.Koskinen LL, et al.. (2009) Association study of the IL18RAP locus in three European populations with coeliac disease. Hum Mol Genet. 18(6): 1148-55.

NCBI and Uniprot Product Information

• NCBI GI #: 4504657
• NCBI GeneID: 8807
• NCBI Accession #: NP_003844.1
• NCBI GenBank Nucleotide #: NM_003853.3
• UniProt Accession #: O95256; Q2QDE5; Q3KPE7; Q3KPE8; Q53TT4; Q53TU5; B2RPJ3
• Molecular Weight: 14,660 Da
• NCBI Official Full Name: interleukin-18 receptor accessory protein
• NCBI Official Synonym Full Names: interleukin 18 receptor accessory protein
• NCBI Official Symbol: IL18RAP
• NCBI Official Synonym Symbols: ACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta
• NCBI Protein Information: interleukin-18 receptor accessory protein
• UniProt Protein Name: Interleukin-18 receptor accessory protein
• Protein Family: Interleukin-18 receptor accessory protein
• UniProt Gene Name: IL18RAP
• UniProt Synonym Gene Names: IL1R7; IL-18 receptor accessory protein; IL-18RAcP; AcPL; IL-1RAcPL; IL-1R-7; IL-1R7; IL-18R-beta; IL-18Rbeta
• UniProt Entry Name: I18RA_HUMAN

NCBI Description

The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

Uniprot Description

IL18RAP: Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Belongs to the interleukin-1 receptor family.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q12

Cellular Component: integral to membrane

Molecular Function: receptor activity

Biological Process: cell surface receptor linked signal transduction; immune response; inflammatory response