Chemical Structure
(Chemical structure of PMA (SIH-508), a PKC kinase activator. CAS #: 16561-29-8. Molecular Formula: C36H58O8. Molecular Weight: 616.8 g/mol.)
PMA small molecule
PMA
Gene Names
HA1; AHA1; F19F24.16; F19F24_16; H(+)-ATPase 1; OPEN STOMATA 2; OST2; PLASMA MEMBRANE PROTON ATPASE; PMA
Purity
>=99% (TLC)
Synonyms
PMA; PKC kinase activator; Phorbol 12-myristate 13-acetate; PMA small molecule
Host
Synthetic
Purity/Purification
>=99% (TLC)
Form/Format
Colorless amorphous film or foam
Sequence Length
949
Solubility
Soluble in DMSO (25 mg/ml), 100% ethanol (25 mg/ml), acetone, ether or dimethyl formamide; almost insoluble in aqueous buffers
CAS Number
16561-29-8
Molecular Formula
C36H58O8
SMILES
O=C(OC41C(C2/C=C(/CO)CC3(O)C(O)C(=C/C3C2(O)C(C)C1OC(=O)CCCCCCCCCCCCC)\C)C4(C)C)C
InChI
1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
InChI Key
PHEDXBVPIONUQT-RGYGYFBISA-N
PubChem CID
27924
Preparation and Storage
Store at -20 degree C.
Chemical Structure
(Chemical structure of PMA (SIH-508), a PKC kinase activator. CAS #: 16561-29-8. Molecular Formula: C36H58O8. Molecular Weight: 616.8 g/mol.)
Chemical Structure
(Chemical structure of PMA (SIH-508), a PKC kinase activator. CAS #: 16561-29-8. Molecular Formula: C36H58O8. Molecular Weight: 616.8 g/mol.)
Related Product Information for PMA small molecule
PMA (Phorbol 12-myristate 13-acetate) is a phorbol ester. It is used experimentally as a reversible protein kinase C (PKC) activator. It has been shown to be a potent tumor promoter.
Product Categories/Family for PMA small molecule
References
1. Murphy T. V., Prountzos C., Kotsonis P., Iannazzo L., & Majewski H. (1999). Euro.J. Pharm. 381(1): 77-84. 2. Castagna M., et al. (1982) J. Biol. Chem. 257(13): 7847-7851.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
616.8
NCBI Official Full Name
PMA
NCBI Official Symbol
HA1
NCBI Official Synonym Symbols
AHA1; F19F24.16; F19F24_16; H(+)-ATPase 1; OPEN STOMATA 2; OST2; PLASMA MEMBRANE PROTON ATPASE; PMA
NCBI Protein Information
H[+]-ATPase 1
UniProt Protein Name
ATPase 1, plasma membrane-type
UniProt Gene Name
AHA1
NCBI Description
Encodes a plasma membrane proton ATPase. Mutants have a reduced ability to close their stomata in response to drought and are affected in stomatal but not seed responsiveness to ABA.
Uniprot Description
The plasma membrane H+ ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses. Forms a functional cation-translocating unit with CNGC17 that is activated by PSKR1/BAK1 and possibly other BAK1/RLK complexes (PubMed:26071421).
Research Articles on PMA
Similar Products
Product Notes
The PMA aha1 (Catalog #AAA808207) is a Small Molecule produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PMA, Small Molecule" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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